ArticleScientific reports2013
The role of shape complementarity in the protein-protein interactions.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 69 citations in OpenAlex.
- Beyond contacts: The important role of the support region in protein complex assembly.Protein science : a publication of the Protein Society · 2026Article
- A Complementarity-Based Approach to De Novo Binder Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Shape-Complementarity Approach to Inducing Short Au(III)···Au(III) Contacts in Tetracyanoaurate(III) Salts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Zepyros: a webserver to evaluate the shape complementarity of protein-protein interfaces.Bioinformatics advances · 2025Article
- Entropy-Mediated Nanoparticle Cellular Uptake.Small science · 2024Article
- Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management.Scientific reports · 2023Review
- Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors.PLoS computational biology · 2022Article
- High affinity protein surface binding through co-engineering of nanoparticles and proteins.Nanoscale · 2022Article
- The eptinezumab:CGRP complex structure - the role of conformational changes in binding stabilization.Bioengineered · 2021Article
- Understanding crown shyness from a 3-D perspective.Annals of botany · 2021Article
- Article
- Targeting protein-protein interaction interfaces in COVID-19 drug discovery.Computational and structural biotechnology journal · 2021Review
- Annexin B12 Trimer Formation is Governed by a Network of Protein-Protein and Protein-Lipid Interactions.Scientific reports · 2020Article
- Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations.Scientific reports · 2019Article
- A simulated intermediate state for folding and aggregation provides insights into ΔN6 β2-microglobulin amyloidogenic behavior.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use a dissipative particle dynamic simulation to investigate the effects of shape complementarity on the protein-protein interactions. By monitoring different kinds of protein shape-complementarity modes, we gave a clear mechanism to reveal the role of the shape complementarity in the protein-protein interactions, i.e., when the two proteins with shape complementarity approach each other, the conformation of lipid chains between two proteins would be restricted significantly. The lipid molecules tend to leave the gap formed by two proteins to maximize the configuration entropy, and therefore yield an effective entropy-induced protein-protein attraction, which enhances the protein aggregation. In short, this work provides an insight into understanding the importance of the shape complementarity in the protein-protein interactions especially for protein aggregation and antibody-antigen complexes. Definitely, the shape complementarity is the third key factor affecting protein aggregation and complex, besides the electrostatic-complementarity and hydrophobic complementarity.
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