Evidence map›Paper›PMID 24253283›Full record

ReviewViruses2013

Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication.

Matthew S Stake, Darrin V Bann, Rebecca J Kaddis, Leslie J Parent

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Measuring the subcellular compartmentalization of viral infections by protein complementation assay.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew S StakeDivision of Infectious Diseases and Epidemiology, Department of Medicine, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA. lparent@psu.edu.
Darrin V Bann
Rebecca J Kaddis
Leslie J Parent
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

The Center for HIV RNA Studies (CRNA)P50GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUMMERS, MICHAEL FINLEY · 2012 to 2016
$21.7M
Nuclear Trafficking of the Retroviral Gag ProteinR01CA076534 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PARENT, LESLIE J · 1998 to 2018
$5.2M
Host RNA Processing Factors: Friend or Foe of Oncogenic RetroelementsF30CA165774 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BANN, DARRIN V · 2012 to 2015
$118k
Nuclear Export of Retroviral RNPs: Cytoplasmic fates determined in the nucleusF31CA171862 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MALDONADO, REBECCA J.R. KADDIS · 2012 to 2015
$111k
NCI NIH HHS F30 CA165774NCI NIH HHS F31 CA171862NCI NIH HHS R01 CA076534NCI NIH HHS R01CA76534NIGMS NIH HHS P50 GM103297NIGMS NIH HHS P50GM103297
6 · The paper itself

Abstract

Retroviruses exploit nuclear trafficking machinery at several distinct stages in their replication cycles. In this review, we will focus primarily on nucleocytoplasmic trafficking events that occur after the completion of reverse transcription and proviral integration. First, we will discuss nuclear export of unspliced viral RNA transcripts, which serves two essential roles: as the mRNA template for the translation of viral structural proteins and as the genome for encapsidation into virions. These full-length viral RNAs must overcome the cell's quality control measures to leave the nucleus by co-opting host factors or encoding viral proteins to mediate nuclear export of unspliced viral RNAs. Next, we will summarize the most recent findings on the mechanisms of Gag nuclear trafficking and discuss potential roles for nuclear localization of Gag proteins in retrovirus replication.

Indexed as

Virus ReplicationAnimalsCell Nucleusgag Gene Products, Human Immunodeficiency VirusHumansProtein TransportRetroviridaeRetroviridae Infectionsgag Gene Products, Human Immunodeficiency Virus

Identifiers

PMID24253283
PMCPMC3856414
OpenAlexW2128485693

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.