ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Clinical subtypes in Parkinson's disease: the impact of MAPT haplotypes.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Tau and MAPT genetics in tauopathies and synucleinopathies.Parkinsonism & related disorders · 2021Review
- iPS Cell-Based Model forFrontiers in cell and developmental biology · 2021Article
- Association of MAPT subhaplotypes with clinical and demographic features in Parkinson's disease.Annals of clinical and translational neurology · 2020Article
- The effect of MAPT haplotype on neocortical Lewy body pathology in Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Genetic Architecture of MAPT Gene Region in Parkinson Disease Subtypes.Frontiers in cellular neuroscience · 2016Article
- Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The H1 haplotype of the MAPT gene influences the risk of PD and has been related to the development of PDD. We evaluated the influence of MAPT haplotypes on the expression of motor features in PD patients. We genotyped, for the MAPT haplotypes H1 and H2, a sample of 181 PD patients with distinct clinical subtypes: tremor dominant and non-tremor dominant (NTD). Our results indicate that the MAPT haplotypes contribute to the expression of motor features of PD. H1 homozygous PD patients are significantly more likely to present a NTD phenotype, a clinical subtype characterized by widespread pathological degeneration, than H2 carriers.
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