ArticleMolecular plant2014
New insights into aluminum tolerance in rice: the ASR5 protein binds the STAR1 promoter and other aluminum-responsive genes.
Article in Molecular plant, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 134 citations in OpenAlex.
- Integrative genomics resolves rice loci associated with acidic soil-related aluminum, cadmium, and manganese stress responses.Plant cell reports · 2026Article
- The Transcription Factor OsWRKY64 Interacts With OsART1 to Positively Regulate Al Resistance in Rice.Plant biotechnology journal · 2026Article
- Integrated morphological, physiological, and transcriptomic profiling unveils a root-centric defense network mediating aluminum tolerance in Trifolium repens L.BMC plant biology · 2026Article
- The MaASR3-MaHDT1 module modulates high-temperature-inhibited chlorophyll breakdown in banana fruit by suppressing the E3 ligase MaNIP1.Horticulture research · 2025Article
- The RAE1-STOP1 module regulates ABA sensitivity in early seedlings of Arabidopsis.BMC plant biology · 2025Article
- Profiling of Key Hub Genes Using a Two-State Weighted Gene Co-Expression Network of 'Jao Khao' Rice under Soil Salinity Stress Based on Time-Series Transcriptome Data.International journal of molecular sciences · 2024Article
- Genome-Wide Identification of the PeanutInternational journal of molecular sciences · 2024Article
- Development History, Structure, and Function ofInternational journal of molecular sciences · 2024Review
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- Gibberellin-Mediated Sensitivity of Rice Roots to Aluminum Stress.Plants (Basel, Switzerland) · 2024Article
- Review
- Regulation of Drought and Salt Tolerance by OsSKL2 and OsASR1 in Rice.Rice (New York, N.Y.) · 2022Article
- Article
- Circadian Rhythm Regulates Reactive Oxygen Species Production and Inhibits Al-Induced Programmed Cell Death in Peanut.Life (Basel, Switzerland) · 2022Article
- Whole-genome DNA methylation patterns ofPlant direct · 2022Article
- Article
- Regulatory network established by transcription factors transmits drought stress signals in plant.Stress biology · 2022Review
- OsASR6 Alleviates Rice Resistance toInternational journal of molecular sciences · 2022Article
- Grape ASR-Silencing Sways Nuclear Proteome, Histone Marks and Interplay of Intrinsically Disordered Proteins.International journal of molecular sciences · 2022Article
- Abscisic Acid-Stress-Ripening Genes Involved in Plant Response to High Salinity and Water Deficit in Durum and Common Wheat.Frontiers in plant science · 2022Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Aluminum (Al) toxicity in plants is one of the primary constraints in crop production. Al³⁺, the most toxic form of Al, is released into soil under acidic conditions and causes extensive damage to plants, especially in the roots. In rice, Al tolerance requires the ASR5 gene, but the molecular function of ASR5 has remained unknown. Here, we perform genome-wide analyses to identify ASR5-dependent Al-responsive genes in rice. Based on ASR5_RNAi silencing in plants, a global transcriptome analysis identified a total of 961 genes that were responsive to Al treatment in wild-type rice roots. Of these genes, 909 did not respond to Al in the ASR5_RNAi plants, indicating a central role for ASR5 in Al-responsive gene expression. Under normal conditions, without Al treatment, the ASR5_RNAi plants expressed 1.756 genes differentially compared to the wild-type plants, and 446 of these genes responded to Al treatment in the wild-type plants. Chromatin immunoprecipitation followed by deep sequencing identified 104 putative target genes that were directly regulated by ASR5 binding to their promoters, including the STAR1 gene, which encodes an ABC transporter required for Al tolerance. Motif analysis of the binding peak sequences revealed the binding motif for ASR5, which was confirmed via in vitro DNA-binding assays using the STAR1 promoter. These results demonstrate that ASR5 acts as a key transcription factor that is essential for Al-responsive gene expression and Al tolerance in rice.
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