ArticleThe Journal of biological chemistry2014
Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification and analysis of major latex protein (Frontiers in plant science · 2024Article
- Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5.Frontiers in allergy · 2023Review
- Impact of oligomerization on the allergenicity of allergens.Clinical and molecular allergy : CMA · 2022Review
- Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.Scientific reports · 2021Article
- Dismantling and Rebuilding the Trisulfide Cofactor Demonstrates Its Essential Role in Human Sulfide Quinone Oxidoreductase.Journal of the American Chemical Society · 2020Article
- Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgGInternational journal of molecular sciences · 2020Article
- Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy.Nature chemical biology · 2019Article
- Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Effect of tomato variety, cultivation, climate and processing on Sola l 4, an allergen from Solanum lycopersicum.PloS one · 2018Article
- Common solvents for making extraction of allergenic proteins from plants' pollens for prick tests and related factors: a technical review.Electronic physician · 2017Review
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Structural insights into the IgE mediated responses induced by the allergens Hev b 8 and Zea m 12 in their dimeric forms.Scientific reports · 2016Article
- Article
- Structure-based characterization of multiprotein complexes.Structure (London, England : 1993) · 2014Article
- The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.PloS one · 2014Article
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Authors and funding
11 authors.
Funding
Abstract
Many allergens share several biophysical characteristics, including the capability to undergo oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so far poorly understood. Here, we report crystal structures of dimeric Bet v 1, revealing a noncanonical incorporation of cysteine at position 5 instead of genetically encoded tyrosine. Cysteine polysulfide bridging stabilized different dimeric assemblies, depending on the polysulfide linker length. These dimers represent quaternary arrangements that are frequently observed in related proteins, reflecting their prevalence in unmodified Bet v 1. These conclusions were corroborated by characteristic immunologic properties of monomeric and dimeric allergen variants. Hereby, residue 5 could be identified as an allergenic hot spot in Bet v 1. The presented results refine fundamental principles in protein chemistry and emphasize the importance of protein modifications in understanding the molecular basis of allergenicity.
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