ArticleeLife2013
Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Managing disorders of consciousness: the role of electroencephalography.Journal of neurology · 2021Pooled it
- Transcutaneous auricular vague nerve stimulation improved brain connection activity on patients of disorders of consciousness: a pilot study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Trial
- Behavioral and electrophysiological effects of network-based frontoparietal tDCS in patients with severe brain injury: A randomized controlled trial.NeuroImage. Clinical · 2020Trial
- Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study.Functional neurologyTrial
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- [Guangdong consensus on integrated Chinese and Western medicine management of prolonged disorders of consciousness].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Prognostic factors in prolonged disorders of consciousness: a narrative review.Reviews in the neurosciences · 2026Review
- Exploring the role of zolpidem in alleviating cognitive and motor impairments in chronic cerebral hypoperfusion: a rat model study with in vivo and in silico insights.Experimental animals · 2026Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- Spinal Cord Stimulation for Prolonged Disorders of Consciousness: A Study on Scalp Electroencephalography.CNS neuroscience & therapeutics · 2024Article
- Recovery of consciousness after acute brain injury: a narrative review.Journal of intensive care · 2024Review
- Article
- Review
- Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury.Scientific reports · 2024Article
- Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery.CNS neuroscience & therapeutics · 2024Article
- Injury patterns associated with cognitive motor dissociation.Brain : a journal of neurology · 2023Article
- Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Arousal Regulation by the External Globus Pallidus: A New Node for the Mesocircuit Hypothesis.Brain sciences · 2023Article
- Case Report: Zolpidem's paradoxical restorative action: A case report of functional brain imaging.Frontiers in neuroscience · 2023Article
- Current and Potential Pharmacologic Therapies for Traumatic Brain Injury.Pharmaceuticals (Basel, Switzerland) · 2022Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6-10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7-0.8) within and between hemispheres. Zolpidem administration sharply reduces EEG power and coherence at these low frequencies. The ∼6-10 Hz activity is proposed to arise from intrinsic membrane properties of pyramidal neurons that are passively entrained across the cortex by locally-generated spontaneous activity. Activation by zolpidem is proposed to arise from a combination of initial direct drug effects on cortical, striatal, and thalamic populations and further activation of underactive brain regions induced by restoration of cognitively-mediated behaviors. DOI: http://dx.doi.org/10.7554/eLife.01157.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.