Evidence map›Paper›PMID 24252328›Full record

ArticleBiomarker research2013

Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.

Woodrow J Coker, Ashley Jeter, Henning Schade, Yubin Kang

Open access · goldAbstract read
In one paragraph

Article in Biomarker research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Perioperative considerations for patients with multiple myeloma.European journal of anaesthesiology and intensive care · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Refractory primary extramedullary plasmacytoma in kidney: a case report.The Journal of international medical research · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Extramedullary plasmacytoma of the ureter in an HIV-positive patient.International cancer conference journal · 2017
    Article
  17. Plasma Cell Disorders in HIV Infected Patients: A Case Series.Journal of clinical and diagnostic research : JCDR · 2017
    Article
  18. Article
  19. Review
  20. Current knowledge on HIV-associated Plasmablastic Lymphoma.Mediterranean journal of hematology and infectious diseases · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Woodrow J CokerDivision of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, 86 Jonathan Lucas Street, Hollings Cancer Center, Room# HO307, Charleston, SC, 29425, USA. kangy@musc.edu.
Ashley Jeter
Henning Schade
Yubin Kang
Medical University of South Carolina · USMUSC Hollings Cancer Center · US

Funding

Plerixafor for allogeneic hematopoietic stem cell transplantationK08HL103780 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KANG, YUBIN · 2011 to 2015
$649k
NHLBI NIH HHS K08 HL103780
6 · The paper itself

Abstract

Highly active antiretroviral therapy (HAART) has significantly improved the outcome and survival of human immunodeficiency virus (HIV)-infected patients. Subsequently, long-term morbidities including cancer have become of major public health and clinical interest for this patient population. Plasma cell disorders occur at higher incidence in HIV-infected patients; however, the molecular mechanisms driving the plasma cell disease process and the optimal management for these patients remain to be defined. This article provides an up-to-date review of the characteristics and management of HIV-infected patients with plasma cell disorders. We first present 3 cases of plasma cell disorders in HIV-infected patients, ranging from polyclonal hypergammaglobulinemia to symptomatic multiple myeloma. We then discuss the epidemiology, clinical presentation, and management of each of these plasma cell disorders, with an emphasis on the molecular events underlying the progression of plasma cell diseases from monoclonal gammopathy to symptomatic multiple myeloma. We propose a three-step hypothesis for the development of multiple myeloma. Finally, we discuss the use of high dose chemotherapy and autologous hematopoietic stem cell transplantation in the treatment of HIV-infected patients with multiple myeloma. Our review includes the care of HIV-infected patients with plasma cell disorders in the current era of HAART and novel agents available for the treatment of multiple myeloma.

Identifiers

PMID24252328
PMCPMC4177611
OpenAlexW2131095326

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.