ArticleBiomarker research2013
Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model.
Article in Biomarker research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Role of Mitochondrial Optical Redox Imaging in Modern Cancer Research (2024 Peter Vaupel Honorary Lecture).Advances in experimental medicine and biology · 2026Article
- Fast autofluorescence imaging to evaluate dynamic changes in cell metabolism.Journal of biomedical optics · 2024Article
- Quantitative Optical Redox Imaging of Melanoma Xenografts with Different Metastatic Potentials.Cancers · 2024Article
- Optical redox imaging of ANT1-deficient muscles.Journal of innovative optical health sciences · 2024Article
- Development of an Endoscopic Auto-Fluorescent Sensing Device to Aid in the Detection of Breast Cancer and Inform Photodynamic Therapy.Metabolites · 2022Article
- Sex and SP-A2 Dependent NAD(H) Redox Alterations in Mouse Alveolar Macrophages in Response to Ozone Exposure: Potential Implications for COVID-19.Antioxidants (Basel, Switzerland) · 2020Article
- Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer.Biomaterials · 2019Article
- Optical Redox Imaging of Lonidamine Treatment Response of Melanoma Cells and Xenografts.Molecular imaging and biology · 2019Article
- Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information.Molecular imaging and biology · 2019Article
- Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells.Molecular imaging and biology · 2019Article
- Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD.Antioxidants & redox signaling · 2019Review
- Differential Expression of PGC1α in Intratumor Redox Subpopulations of Breast Cancer.Advances in experimental medicine and biology · 2018Article
- Optical redox imaging indices discriminate human breast cancer from normal tissues.Journal of biomedical optics · 2016Article
- Imaging metabolic heterogeneity in cancer.Molecular cancer · 2016Review
- Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma.Neoplasia (New York, N.Y.) · 2014Article
- Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI.Molecular imaging and biology · 2014Article
- Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity.Journal of innovative optical health sciences · 2014Article
- 3D IMAGING OF THE MITOCHONDRIAL REDOX STATE OF RAT HEARTS UNDER NORMAL AND FASTING CONDITIONS.Journal of innovative optical health sciences · 2014Article
- Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate.Academic radiology · 2014Article
- Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging.SpringerPlus · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMetabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. Pancreas-specific deletion of PTEN in mouse caused progressive premalignant lesions such as highly proliferative ductal metaplasia. We imaged the mitochondrial redox state of the pancreases of the transgenic mice approximately eight months old using the redox scanner, i.e., the nicotinamide adenine dinucleotide/oxidized flavoproteins (NADH/Fp) fluorescence imager at low temperature. Two different approaches, the global averaging of the redox indices without considering tissue heterogeneity along tissue depth and the univariate analysis of multi-section data using tissue depth as a covariate were adopted for the statistical analysis of the multi-section imaging data. The standard deviations of the redox indices and the histogram analysis with Gaussian fit were used to determine the tissue heterogeneity.
resultsAll methods show consistently that the PTEN deficient pancreases (Pdx1-Cre;PTENlox/lox) were significantly more heterogeneous in their mitochondrial redox state compared to the controls (PTENlox/lox). Statistical analysis taking into account the variations of the redox state with tissue depth further shows that PTEN deletion significantly shifted the pancreatic tissue to an overall more oxidized state. Oxidization of the PTEN-null group was not seen when the imaging data were analyzed by global averaging without considering the variation of the redox indices along tissue depth, indicating the importance of taking tissue heterogeneity into account for the statistical analysis of the multi-section imaging data.
conclusionsThis study reveals a possible link between the mitochondrial redox state alteration of the pancreas and its malignant transformation and may be further developed for establishing potential metabolic biomarkers for the early diagnosis of pancreatic cancer.
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