ArticleActa neuropathologica communications2013
Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function.
Article in Acta neuropathologica communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- What Happens in TBI? A Wide Talk on Animal Models and Future Perspective.Current neuropharmacology · 2023Review
- Environmental Enrichment and Estrogen Upregulate Beta-Hydroxybutyrate Underlying Functional Improvement.Frontiers in molecular neuroscience · 2022Article
- 17β-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury.Antioxidants (Basel, Switzerland) · 2021Article
- Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction.Frontiers in aging neuroscience · 2021Article
- Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy.Frontiers in cellular and infection microbiology · 2021Article
- Combined Effects of Repetitive Mild Traumatic Brain Injury and Alcohol Drinking on the Neuroinflammatory Cytokine Response and Cognitive Behavioral Outcomes.Brain sciences · 2020Article
- (-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies.Bio-protocol · 2020Article
- Article
- Intermittent Administration of Haloperidol after Cortical Impact Injury Neither Impedes Spontaneous Recovery Nor Attenuates the Efficacy of Environmental Enrichment.Journal of neurotrauma · 2019Article
- Exercising New Neurons to Vanquish Alzheimer Disease.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors.Scientific reports · 2018Article
- Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.Neuroscience and biobehavioral reviews · 2018Review
- Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice.CNS neuroscience & therapeutics · 2018Article
- Post-weaning Environmental Enrichment in Male CD-1 Mice: Impact on Social Behaviors, Corticosterone Levels and Prefrontal Cytokine Expression in Adulthood.Frontiers in behavioral neuroscience · 2018Article
- Environmental Enrichment Mitigates Deficits after Repetitive Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Potential for use of creatine supplementation following mild traumatic brain injury.Concussion (London, England) · 2017Review
Corrections and comments
- Expression of concern · 2021-09-29Concerns/Issues about Data · Updated to Retraction · · Teresita Briones has ORI finding of misconduct;
- Retraction · 2022-05-17Concerns/Issues about Data · Duplication of/in Image · Unreliable Data · Upgrade/Update of Prior Notice(s) · · Teresita Briones has ORI finding of misconduct;
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPersistent neuroinflammation and disruptions in brain energy metabolism is commonly seen in traumatic brain injury (TBI). Because of the lack of success of most TBI interventions and the documented benefits of environmental enrichment (EE) in enhancing brain plasticity, here we focused our study on use of EE in regulating injury-induced neuroinflammation and disruptions in energy metabolism in the prefrontal cortex and hippocampus. Adult male Wistar rats were used in the study and randomly assigned to receive either: mild TBI (mTBI) using the controlled cortical injury model or sham surgery. Following surgery, rats from each group were further randomized to either: EE housing or standard laboratory housing (CON). After 4 weeks of recovery, cognitive testing was performed using the non-matching-to-sample and delayed non-matching-to-sample tasks. After completion of behavioral testing, levels of the pro-inflammatory cytokines IL-1β and TNF-α and the anti-inflammatory cytokine IL-10 were measured. In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK (ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis.
resultsOur results showed that EE: (1) decreased the pro-inflammatory cytokines IL-1β and TNF-α and enhanced levels of the anti-inflammatory cytokine IL-10 after mTBI; (2) mitigated mTBI-induced cognitive impairment; and (3) attenuated mTBI-induced downregulation in pAMPK/AMPK ratio and uMtCK levels.
conclusionsOur data demonstrated the potential of EE to modulate the persistent: (1) neuroinflammatory response seen following mTBI, and (2) persistent disturbance in brain energy homeostasis. It is possible that through the mechanism of modulating neuroinflammation, EE housing was able to restore the disruption in energy metabolism and enhanced functional recovery after mTBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.