ArticleMetabolic syndrome and related disorders2014
Insulin resistance and impaired mitochondrial function in obese adolescent girls.
Article in Metabolic syndrome and related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Muscle Strength and Fitness in Pediatric Obesity: a Systematic Review from the European Childhood Obesity Group.Obesity facts · 2016Pooled it
- The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview.Current obesity reports · 2021Review
- High-fat diet affects skeletal muscle mitochondria comparable to pressure overload-induced heart failure.Journal of cellular and molecular medicine · 2020Article
- Sex-specific metabolic functions of adipose Lipocalin-2.Molecular metabolism · 2019Article
- Identifying Metabolomic Profiles of Insulinemic Dietary Patterns.Metabolites · 2019Article
- The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats.Physiological reports · 2018Article
- Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children.International journal of obesity (2005) · 2017Article
- Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.The Journal of clinical endocrinology and metabolism · 2017Article
- Obesity-related differences in neuromuscular fatigue in adolescent girls.European journal of applied physiology · 2015Article
- Mitochondria: diversity in the regulation of the NLRP3 inflammasome.Trends in molecular medicine · 2015Review
- Early oxidative shifts in mouse skeletal muscle morphology with high-fat diet consumption do not lead to functional improvements.Physiological reports · 2014Article
- Effects of recombinant human growth hormone (rhGH) administration on body composition and cardiovascular risk factors in obese adolescent girls.International journal of pediatric endocrinology · 2014Article
- Crosstalk between circulating peroxisome proliferator-activated receptor gamma, adipokines and metabolic syndrome in obese subjects.Diabetology & metabolic syndrome · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMitochondrial dysfunction plays a role in the development of muscle insulin resistance (IR) and the accumulation of intramyocellular lipid (IMCL) in skeletal muscle that can, in turn, interfere with insulin signaling. The purpose of this study was to assess mitochondrial function (MF) and IMCL in obese adolescent girls with and without IR to determine whether: (1) Girls with IR have impaired MF, and (2) impaired MF in girls with IR is related to higher IMCL.
methodsWe examined 22 obese girls aged 13-21 years old for IR [defined as a homeostasis model assessment of insulin resistance (HOMA-IR) value >4. Phosphorus magnetic resonance spectroscopy (31P-MRS) and proton magnetic resonance spectroscopy (1H-MRS), respectively, were used to determine MF and IMCL of the soleus muscle along with magnetic resonance imaging (MRI) measures of visceral, subcutaneous, and total adipose tissue (VAT, SAT, and TAT) in girls with HOMA-IR >4 (insulin-resistant group) versus HOMA-IR ≤ 4 (insulin-sensitive group). Serum lipids and waist-to-hip ratio (W/H) were also measured.
resultsGirls with IR (n=8) did not differ from the insulin-sensitive group (n=14) for age, bone age, weight, VAT, SAT, TAT, or IMCL. However, the insulin-resistant group had higher W/H. Additionally the insulin-resistance group had a lower log rate of postexercise phosphocreatine (PCr) recovery (ViPCr) and a higher log PCr recovery constant (tau), indicative of impaired MF.
conclusionsObese girls with increased IR have impaired mitochondrial function. This association is not mediated by alterations in IMCL or adipose tissue. Further studies are necessary to determine whether there is a causal relation between impaired mitochondrial function and IR in obesity and mediators of such a relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.