ReviewThyroid : official journal of the American Thyroid Association2014
Intrinsic regulation of thyroid function by thyroglobulin.
Review in Thyroid : official journal of the American Thyroid Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels.International journal of molecular sciences · 2022Pooled it
- Effects of Iodized Salt and Iodine Supplements on Prenatal and Postnatal Growth: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Serum thyroglobulin levels are predictive of urinary iodine concentration thresholds for defining population iodine status.The British journal of nutrition · 2025Article
- The role of the primary cilium in thyroid function and dysfunction with implications for thyroid disease.Histochemistry and cell biology · 2025Review
- Gestational age and fetal hypothyroidism Alter the porcine thyroid and local hepatic and renal renin-angiotensin systems.Physiological reports · 2025Article
- PERK/eIF2α pathway affected the thyroid hormone synthetic in hypertensive disorders of pregnancy rats.Frontiers in endocrinology · 2025Article
- Article
- A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka.Environmental science & technology · 2024Article
- Primary human thyrocytes maintained the function of thyroid hormone production and secretion in vitro.Journal of endocrinological investigation · 2023Article
- Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.International journal of molecular sciences · 2023Article
- Optimizing Growth: The Case for Iodine.Nutrients · 2023Review
- Does Iodine Influence the Metabolism of Glucose?Medicina (Kaunas, Lithuania) · 2023Review
- A glance at post-translational modifications of human thyroglobulin: potential impact on function and pathogenesis.European thyroid journal · 2022Review
- Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.Nature communications · 2022Article
- Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development.Disease models & mechanisms · 2022Article
- The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.Frontiers in pharmacology · 2022Review
- Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion.Frontiers in endocrinology · 2022Review
- Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.JCI insight · 2021Article
- Cryo-EM: A new dawn in thyroid biology.Molecular and cellular endocrinology · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4). However, speculation regarding the cause of the functional and morphologic heterogeneity of the follicles that make up the thyroid gland has given rise to the proposition that Tg is not only a precursor of thyroid hormones, but that it also functions as an important signal molecule in regulating thyroid hormone biosynthesis. SUMMARY: Evidence supporting this alternative paradigm of Tg function, including the up- or downregulation by colloidal Tg of the transcription of Tg, iodide transporters, and enzymes employed in Tg iodination, and also the effects of Tg on the proliferation of thyroid and nonthyroid cells, is examined in the present review. Also discussed in detail are potential mechanisms of Tg signaling in follicular cells.
conclusionsFinally, we propose a mechanism, based on experimental observations of Tg effects on thyroid cell behavior, that could account for the phenomenon of follicular heterogeneity as a highly regulated cycle of increasing and decreasing colloidal Tg concentration that functions to optimize thyroid hormone production through the transcriptional activation or suppression of specific genes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.