ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Association of metabolite concentrations and water diffusivity in normal appearing brain tissue with glioma grade.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Enhancing glioma progression prediction: Unsupervised clustering of whole-brain magnetic resonance spectroscopy data for surgical planning.Clinical neurology and neurosurgery · 2026Article
- Metabolic signatures derived from whole-brain MR-spectroscopy identify early tumor progression in high-grade gliomas using machine learning.Journal of neuro-oncology · 2024Article
- AssociatingAJNR. American journal of neuroradiology · 2023Article
- Proton metabolic mapping of the brain at 7 T using a two-dimensional free induction decay-echo-planar spectroscopic imaging readout with lipid suppression.NMR in biomedicine · 2022Article
- The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings.Metabolites · 2022Article
- Accelerated MR spectroscopic imaging-a review of current and emerging techniques.NMR in biomedicine · 2021Review
- Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.NMR in biomedicine · 2021Article
- T1-weighted and T2-weighted Subtraction MR Images for Glioma Visualization and Grading.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- The Association between Whole-Brain MR Spectroscopy and IDH Mutation Status in Gliomas.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Value of diffusion kurtosis imaging in assessing low-grade gliomas.Journal of magnetic resonance imaging : JMRI · 2018Article
- Global brain metabolic quantification with whole-head proton MRS at 3 T.NMR in biomedicine · 2017Article
- Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T.Magnetic resonance imaging · 2017Article
- Increased diffusion in the normal appearing white matter of brain tumor patients: is this just tumor infiltration?Journal of neuro-oncology · 2016Article
- Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.Journal of magnetic resonance imaging : JMRI · 2016Article
- Whole Brain ¹H-Spectroscopy: A Developing Technique for Advanced Analysis of Cerebral Metabolism.Clinical neuroradiology · 2015Review
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Authors and funding
10 authors.
Funding
Abstract
background and purposeStudies of brain tumors have identified altered tissue metabolism and water diffusion in MRI normal appearing tissue regions. In this retrospective study the relationship of these imaging measures with tumor grade in gliomas was investigated.
methodsMR spectroscopic imaging of whole brain and mean diffusivity (MD) measurements were obtained in subjects with untreated glioma and from normal control subjects. Mean metabolite values for N-acetylaspartate (NAA), total creatine (Cre), and total choline (Cho) were obtained in gray- and white-matter regions for the hemisphere contralateral to the tumor location, and MD values were obtained from contralateral normal-appearing white matter. Analyses tested for differences in mean values between subject groups while accounting for age.
resultsAnalysis demonstrated increased NAA/Cre and MD, and decreased Cho/NAA for all tumor grades relative to control values. Differences between tumor grades were also observed for NAA, NAA/Cre, and Cho/NAA. Abnormal values of water diffusion were also observed, but with only a weak association between alterations in diffusion and tissue metabolites.
conclusionsThis study supports previous observations of altered tissue metabolism and water diffusion in normal-appearing white matter while additionally finding differences of metabolite values in gray matter and an association with tumor grade.
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