ReviewInternational wound journal2013
Negative pressure wound therapy: past, present and future.
Review in International wound journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02712164 (Molecular, Histologic, and Clinical Analysis of Negative Pressure Wound Therapy), which is not on this map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular, Histologic, and Clinical Analysis of Negative Pressure Wound Therapy (NPWT) for Split-thickness Skin Graft (STSG) Donor Sites
Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in Chronic Diabetic Wound Healing: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective.The British journal of surgery · 2025Pooled it
- Negative pressure wound therapy in the management of postoperative spinal wound infections: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Update on therapeutic strategy for esophageal anastomotic leak: A systematic literature review.Thoracic cancer · 2023Pooled it
- Simplified vacuum dressing system: effectiveness and safety in wounds management.Acta cirurgica brasileira · 2022Trial
- Phase II Randomized Trial of Negative-Pressure Wound Therapy to Decrease Surgical Site Infection in Patients Undergoing Laparotomy for Gastrointestinal, Pancreatic, and Peritoneal Surface Malignancies.Journal of the American College of Surgeons · 2017Trial
- Handcrafted Vacuum-Assisted Device for Skin Ulcers Treatment Versus Traditional Therapy, Randomized Controlled Trial.World journal of surgery · 2017Trial
- Negative pressure wound therapy in infants with complex abdominal wounds: A systematic review of clinical applications and closure strategies.JPRAS open · 2026Review
- Current Incisional Negative Pressure Wound Therapy Systems: Technical Characteristics and a Decision Framework for Device Selection.International wound journal · 2026Review
- Bioactive Compound-Integrated Metal Nanoparticles Promote Wound Repair in Diabetic Conditions: Evidence from an Animal Study.Applied biochemistry and biotechnology · 2026Review
- Eight-month functional and scar outcomes following conservative management of an extensive diabetic foot soft-tissue defect using high-purity type I collagen matrix and negative pressure wound therapy: a case report.Journal of surgical case reports · 2026Article
- Reverse Aqua Pump Negative Pressure Wound Therapy: A Noninferiority Randomized Controlled Trial of Effectiveness and Affordability in Optimizing the Inflammatory and Proliferative Phases of Wound Healing in Developing Countries.Journal of hand surgery global online · 2026Article
- Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions.International wound journal · 2026Review
- The Piezo1-Ca2+-PI3k/Akt signaling axis as a context-dependent mechanotransduction node during skin wound healing.iScience · 2026Review
- Advanced Grafting Biomaterials and Technologies in Chronic Wound Care: Mechanisms, Clinical Outcomes, and Therapeutic Integration.Journal of functional biomaterials · 2026Review
- Negative Pressure Wound Therapy for Complex Perianal Fistulas: A Case Series.International wound journal · 2026Article
- Integrating Negative-Pressure Wound Therapy in the Therapeutic Protocol of Extensive Pediatric Burns: Current Practice and Further Treatment Decision Algorithm.Medicina (Kaunas, Lithuania) · 2026Article
- Particulate Evacuation Under NPWT: Bench Evaluation of a Multilayer Foam Prototype Versus Commercial Dressings in a Simulated Exudate Model.International wound journal · 2026Article
- Efficacy and Economic Impact of PICO-7 Dressings in Preventing Surgical Site Infections After Posterior Lumbar Fusion: A Matched Case-Control Study.International journal of spine surgery · 2026Article
- Simplified Negative Pressure Wound Therapy: A Cost-Effective Solution for Wound Management.Journal of orthopaedic case reports · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative pressure wound therapy (NPWT), which was introduced as a commercial product (V.A.C. Therapy, KCI USA, Inc., San Antonio, TX) less than 20 years ago, has revolutionised the treatment of complex wounds. Indicated for wide variety of wound types, NPWT is an adjunctive therapy that can be used safely in a range of care settings. Current research indicates that there are four primary NPWT mechanisms of action: macrodeformation, microdeformation, fluid removal and environmental control of the wound. The interaction of the primary mechanisms results in secondary effects through cell signalling (e.g. granulation tissue formation, cell proliferation and modulation of inflammation). Better understanding of the mechanisms of action also provides insight into future directions for NPWT research that could create better solutions for patients with complex wounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.