ArticleRespirology (Carlton, Vic.)2014
Detection of viruses and atypical bacteria associated with acute respiratory infection of children in Hubei, China.
Article in Respirology (Carlton, Vic.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Pathogen Profile of Pediatric Community-Acquired Pneumonia in Wuhan, 2023: A BALF-Based Study.Canadian respiratory journal · 2026Article
- Epidemiological characteristics of six common respiratory pathogen infections in children.Microbiology spectrum · 2025Article
- Comparison of the epidemiological characteristics of mycoplasma pneumoniae infections among children during two epidemics in Wuhan from 2018 to 2024.BMC pediatrics · 2025Article
- Identification ofThe Journal of international medical research · 2022Article
- Q Fever as a Cause of Community-Acquired Pneumonia in French Guiana.The American journal of tropical medicine and hygiene · 2022Article
- Total infectome characterization of respiratory infections in pre-COVID-19 Wuhan, China.PLoS pathogens · 2022Article
- Clinical evaluation of a new single-tube multiplex reverse transcription PCR assay for simultaneous detection of 11 respiratory viruses, Mycoplasma pneumoniae and Chlamydia in hospitalized children with acute respiratory infections.Diagnostic microbiology and infectious disease · 2017Article
- Encouraging rational antibiotic use in childhood pneumonia: a focus on Vietnam and the Western Pacific Region.Pneumonia (Nathan Qld.) · 2017Review
- Child pneumonia - focus on the Western Pacific Region.Paediatric respiratory reviews · 2017Review
- Bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in Dhaka city.PloS one · 2017Article
- Community-Acquired Pneumonia in the Asia-Pacific Region.Seminars in respiratory and critical care medicine · 2016Review
- Cultural drivers and health-seeking behaviours that impact on the transmission of pig-associated zoonoses in Lao People's Democratic Republic.Infectious diseases of poverty · 2015Article
- Problem of immunoglobulin M co-detection in serological response to bacterial and viral respiratory pathogens among children suspected of legionellosis.Central-European journal of immunology · 2015Article
- Technical guidelines for the application of seasonal influenza vaccine in China (2014-2015).Human vaccines & immunotherapeutics · 2015Article
- Etiology of community acquired pneumonia among children in India with special reference to atypical pathogens.Lung India : official organ of Indian Chest SocietyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveAcute respiratory infection is the major cause of disease and death in children, particularly in developing countries. However, the spectrum of pathogenic viruses and atypical bacteria that exist in many of these countries remains incompletely characterized. The aim of this study was to examine the spectrum of pathogenic viruses and atypical bacteria associated with acute respiratory infection in children under the age of 16.
methodsA total of 10 435 serum sera specimens were collected from hospitalized children presenting with acute respiratory infection symptoms. Indirect immunofluorescence assays were performed to detect immunoglobulin M antibodies against nine common pathogens: mycoplasma pneumonia, influenza virus B, respiratory syncytial virus, parainfluenza virus, adenovirus, influenza virus A, legionella pneumophila, coxiella burnetii and chamydophila pneumonia.
resultsOf the 10 435 specimens examined, 7046 tested positive for at least one pathogen. Among all of the tested pathogens, mycoplasma pneumonia had the highest detection rate (56.9%). Influenza virus A and influenza virus B epidemics occurred during both winter and summer. The detection rate of respiratory syncytial virus and adenovirus was higher in spring. Cases of mixed infection were more complex: 4136 specimens (39.6%) tested positive for ≥2 pathogens. There were statistically significant difference in detection rates of mycoplasma pneumonia, influenza virus B, respiratory syncytial virus, parainfluenza virus, adenovirus, influenza virus A, legionella pneumophila and chamydophila pneumonia among different age groups (P < 0.05).
conclusionsThe most common pathogens causing acute respiratory infection among children in Hubei of China were mycoplasma pneumonia, influenza virus B and respiratory syncytial virus. The detection rates for each pathogen displayed specific seasonal and age group variations.
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