ArticleAnalytical chemistry2013
Development of a mass spectrometry sampling probe for chemical analysis in surgical and endoscopic procedures.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma.Molecular oncology · 2026Article
- Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis.Proteomics · 2022Review
- Psychosocial impairment following mild blast-induced traumatic brain injury in rats.Behavioural brain research · 2021Article
- A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.Analytical chemistry · 2020Article
- Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system.Science translational medicine · 2017Article
- Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring.Theranostics · 2017Review
- Towards Practical Endoscopic Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Ambient ionization and miniature mass spectrometry system for chemical and biological analysis.Trends in analytical chemistry : TRAC · 2016Article
- In vivo Real-Time Mass Spectrometry for Guided Surgery Application.Scientific reports · 2016Article
- Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation.Clinical chemistry · 2016Review
- Real-time sample analysis using a sampling probe and miniature mass spectrometer.Analytical chemistry · 2015Article
- Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems.Journal of the American Society for Mass Spectrometry · 2015Article
- Visualizing life with ambient mass spectrometry.Current opinion in biotechnology · 2015Review
- Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories.Bioanalysis · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A sampling probe based on ambient desorption ionization was designed for in vivo chemical analysis by mass spectrometry in surgical and endoscopic procedures. Sampling ionization of analytes directly from tissue was achieved by sealing the sampling tip against the tissue surface without allowing leakage of the auxiliary gas used for desorption ionization. The desorbed charged species were transferred over a long distance (up to 4 m) through a flexible tube of internal diameter as small as 1/16 in. to the inlet of the mass spectrometer used for analysis. The conditions used for desorption electrospray ionization (DESI) were optimized to achieve biocompatibility for clinical applications while obtaining adequate efficiency for the analysis. This optimization involved the removal of high voltage and use of pure water as a spray solvent instead of the organic solvents or aqueous mixtures normally used. Improved sensitivity was achieved under these conditions by increasing the gas flow rate in the transfer tube. The destructive effect on tissue surfaces associated with typical desorption ionization was avoided by altering the local gas dynamics in the sample area without compromising the overall analysis efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.