ReviewCurrent pharmaceutical design2014
Melatonin and glucose metabolism: clinical relevance.
Review in Current pharmaceutical design, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03848533 (Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Effect of Melatonin as an Adjunct to NSPT on Periodontal and Systemic Outcomes in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs.Journal of clinical medicine · 2026Review
- Melatonin, an Antitumor Necrosis Factor Therapy.Journal of pineal research · 2025Review
- Article
- Melatonin Receptor 1B Genetic Variants on Susceptibility to Gestational Diabetes Mellitus: A Hospital-Based Case-Control Study in Wuhan, Central China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Effect of melatonin on stress-induced hyperglycemia and insulin resistance in critically-ill patients: A randomized double-blind, placebo-controlled clinical trial.Caspian journal of internal medicine · 2022Article
- Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus.Journal of diabetes and metabolic disorders · 2020Review
- Article
- Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2020Review
- Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes.Bioinformatics (Oxford, England) · 2019Article
- Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish.Endocrine · 2018Article
- Melatonin Uptake by Cells: An Answer to Its Relationship with Glucose?Molecules (Basel, Switzerland) · 2018Review
- Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin's roles in prophylaxis and management.World journal of diabetes · 2018Review
- Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring.Molecules (Basel, Switzerland) · 2018Article
- The Hyperglycemic Effect of Melatonin in the Chinese Mitten Crab,Frontiers in physiology · 2018Article
- Antioxidants of Edible Mushrooms.Molecules (Basel, Switzerland) · 2015Review
- Article
- REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population.PloS one · 2014Article
- A Pre-Exercise Dose of Melatonin Can Alter Substrate Use During Exercise.International journal of exercise scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrations in patients with diabetes. In several recent studies, a single nucleotide polymorphism of the human melatonin receptor 1B has been described as being causally linked to an increased risk of developing type 2 diabetes. Taken together, these data suggest that endogenous as well as exogenous melatonin may play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species, considering pancreatic β-cells are particularly susceptible to oxidative stress because they possess only low-antioxidative capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.