Do pharmacogenetics have a role in the dosing of vitamin K antagonists?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Genotype-guided drug prescribing: a systematic review and meta-analysis of randomized control trials.British journal of clinical pharmacology · 2015
   Pooled it
2. Pharmacogenetics-Based versus Conventional Dosing of Warfarin: A Meta-Analysis of Randomized Controlled Trials.PloS one · 2015
   Pooled it
3. Reduced anticoagulation variability in patients on warfarin monitored with Fiix-prothrombin time associates with reduced thromboembolism: The Fiix-trial.Journal of thrombosis and thrombolysis · 2017
   Trial
4. Educating orally anticoagulated patients in drug safety: a cluster-randomized study in general practice.Deutsches Arzteblatt international · 2014
   Trial
5. Replacement of traditional prothrombin time monitoring with the new Fiix prothrombin time increases the efficacy of warfarin without increasing bleeding. A review article.Thrombosis journal · 2021
   Review
6. Identification and Enzymatic Activity Evaluation of a NovelFrontiers in pharmacology · 2021
   Article
7. Warfarin: The End or the End of One Size Fits All Therapy?Journal of personalized medicine · 2018
   Review
8. VKORC1-1639A allele influences warfarin maintenance dosage among Blacks receiving warfarin anticoagulation: a retrospective cohort study.Future cardiology · 2018
   Article
9. Pharmacological and Non-pharmacological Treatments for Stroke Prevention in Patients with Atrial Fibrillation.Advances in therapy · 2017
   Review
10. Evidence and resources to implement pharmacogenetic knowledge for precision medicine.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2016
    Review
11. The Application of Genomics in Diabetes: Barriers to Discovery and Implementation.Diabetes care · 2016
    Article
12. A systematic analysis and comparison of warfarin initiation strategies.Pharmacogenetics and genomics · 2016
    Article
13. Anticoagulation in Atrial Fibrillation - Current Concepts.Arrhythmia & electrophysiology review · 2015
    Article
14. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation · 2015
    Article
15. Genotype and risk of major bleeding during warfarin treatment.Pharmacogenomics · 2014
    Article
16. Improved drug therapy: triangulating phenomics with genomics and metabolomics.Human genomics · 2014
    Review
17. Stroke genetics: a review and update.Journal of stroke · 2014
    Review
18. Chasing Mendel: five questions for personalized medicine.The Journal of physiology · 2014
    Review
19. Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area.Current psychiatry reviews · 2014
    Article
20. Revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression.CPT: pharmacometrics & systems pharmacology · 2014
    Article

Corrections and comments

• Comment on
  A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.2013
• Comment on
  A pharmacogenetic versus a clinical algorithm for warfarin dosing.2013
• Comment on
  A randomized trial of genotype-guided dosing of warfarin.2013

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as