ArticleNorth American journal of medical sciences2013
Association of sympathovagal imbalance with cardiovascular risks in overt hypothyroidism.
Article in North American journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Turner Syndrome and the Thyroid Function-A Systematic and Critical Review.International journal of molecular sciences · 2024Pooled it
- Heart rate variability in hypothyroid patients: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Evaluation and correlation of heart rate variability and ventricular repolarization parameters in an Indian pediatric clinical hypothyroid population: a prospective cohort study.Scientific reports · 2026Article
- Evaluation of heart rate variability, QT dispersion, and Tp-e interval in pediatric subclinical hypothyroidism.Pediatric research · 2025Article
- Article
- Inflammation and decreased cardiovagal modulation are linked to stress and depression at 36th week of pregnancy in gestational diabetes mellitus.Scientific reports · 2023Article
- Effect of the Marine Exercise Retreat Program on Thyroid-Related Hormones in Middle-Aged Euthyroid Women.International journal of environmental research and public health · 2023Article
- Article
- Linear Analysis of Autonomic Activity and Its Correlation with Creatine Kinase-MB in Overt Thyroid Dysfunctions.Indian journal of clinical biochemistry : IJCB · 2018Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular morbidities have been reported in hypothyroidism.
aimsThe objective of this study is to investigate the link of sympathovagal imbalance (SVI) to cardiovascular risks (CVRs) and the plausible mechanisms of CVR in hypothyroidism. MATERIALS AND
methodsAge-matched 104 females (50 controls, 54 hypothyroids) were recruited and their body mass index (BMI), cardiovascular parameters, autonomic function tests by spectral analysis of heart rate variability (HRV), heart rate response to standing, deep breathing and blood pressure response to isometric handgrip were studied. Thyroid profile, lipid profile, immunological and inflammatory markers were estimated and their association with low-frequency to the high-frequency ratio (LF-HF) of HRV, the marker of SVI was assessed by multivariate regression.
resultsIncreased diastolic pressure, decreased HRV, increased LF-HF, dyslipidemia and increased high-sensitive C-reactive protein (hsCRP) were observed in hypothyroid patients and all these parameters had significant correlation with LF-HF. BMI had no significant association with LF-HF. Atherogenic index (β 1.144, P = 0.001) and hsCRP (b 0.578, P = 0.009) had independent contribution to LF-HF. LF-HF could significantly predict hypertension status (odds ratio 2.05, confidence interval 1.110-5.352, P = 0.008) in hypothyroid subjects.
conclusionsSVI due to sympathetic activation and vagal withdrawal occurs in hypothyroidism. Dyslipidemia and low-grade inflammation, but not obesity contribute to SVI and SVI contributes to cardiovascular risks.
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