ArticleIndian journal of endocrinology and metabolism2013
Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation.
Article in Indian journal of endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Skin Hyperpigmentation: An Under-Recognized Dermatological Clue to Vitamin B12 Deficiency.Clinical case reports · 2026Article
- Relationship Between Hemoglobin, Serum Iron, Iron-Binding Capacity, Ferritin, Zinc, Vitamin B12, and Vitamin D Levels in Patients with Melasma and the Severity of Their Condition.The Eurasian journal of medicine · 2026Article
- Addison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.JCEM case reports · 2026Article
- Article
- Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms.Frontiers in physiology · 2023Review
- New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden.Diagnostics (Basel, Switzerland) · 2022Review
- Knuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report.JNMA; journal of the Nepal Medical Association · 2020Article
- Reversible acral and mucosal hyperpigmentation in a patient with B12 deficiency secondary to polyglandular autoimmune syndrome type II.SAGE open medical case reports · 2020Article
- Knuckle pigmentation, peripheral neuropathy, madness and abnormal movement: is it BNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Vitamin BInternational journal of molecular sciences · 2018Article
- Melanoderma: uncommon presentation of a common condition.BMJ case reports · 2016Article
- Knuckle Pigmentation: A Clue to Systemic Illness.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Article
- Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis.Sultan Qaboos University medical journal · 2015Article
- Reversible ecchymosis and hyperpigmented lesions: A rare presentation of dietary Vitamin B12 deficiency.Journal of family medicine and primary careArticle
- Vitamin B12 deficiency presenting with hyperpigmentation and pancytopenia.Journal of family medicine and primary careArticle
- Addisonian Pigmentation - The Great Mimicker - A Review.Indian journal of dermatologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.
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