Evidence map›Paper›PMID 24251116›Full record

ReviewRedox biology2013

Biological markers of oxidative stress: Applications to cardiovascular research and practice.

Edwin Ho, Keyvan Karimi Galougahi, Chia-Chi Liu, Ravi Bhindi, Gemma A Figtree

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 334 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 5 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 5 syntheses or guidelines pooled it, 800 citations in OpenAlex.

  1. Pooled it
  2. Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024
    Pooled it
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  13. The effects of different doses ofVeterinary and animal science · 2026
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  17. Observational
  18. Essential Oils: Chemistry and Mechanisms of Anticonvulsant Action.International journal of molecular sciences · 2026
    Review
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  20. Review

274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Edwin HoNorth Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.
Keyvan Karimi Galougahi
Chia-Chi Liu
Ravi Bhindi
Gemma A Figtree
University of Sydney · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a common mediator in pathogenicity of established cardiovascular risk factors. Furthermore, it likely mediates effects of emerging, less well-defined variables that contribute to residual risk not explained by traditional factors. Functional oxidative modifications of cellular proteins, both reversible and irreversible, are a causal step in cellular dysfunction. Identifying markers of oxidative stress has been the focus of many researchers as they have the potential to act as an "integrator" of a multitude of processes that drive cardiovascular pathobiology. One of the major challenges is the accurate quantification of reactive oxygen species with very short half-life. Redox-sensitive proteins with important cellular functions are confined to signalling microdomains in cardiovascular cells and are not readily available for quantification. A popular approach is the measurement of stable by-products modified under conditions of oxidative stress that have entered the circulation. However, these may not accurately reflect redox stress at the cell/tissue level. Many of these modifications are "functionally silent". Functional significance of the oxidative modifications enhances their validity as a proposed biological marker of cardiovascular disease, and is the strength of the redox cysteine modifications such as glutathionylation. We review selected biomarkers of oxidative stress that show promise in cardiovascular medicine, as well as new methodologies for high-throughput measurement in research and clinical settings. Although associated with disease severity, further studies are required to examine the utility of the most promising oxidative biomarkers to predict prognosis or response to treatment.

Indexed as

Oxidative StressAnimalsBiomarkersBiomedical ResearchCardiovascular DiseasesHumansBiomarkersBiomarkerCardiovascular diseaseCVD, cardiovascular diseaseGlutathionylationGSH, glutathione (reduced)H2O2, hydrogen peroxideHO2•, hydroperoxyl radicalHOCl, hypochlorous acidIsoP, isoprostaneMDA, malondialdehydeMPO, myeloperoxidaseNO2, nitrogen dioxideO2•−, superoxide•OH, hydroxyl radicalONOO−, peroxynitriteOxidative stressOxLDL, Oxidized low-density lipoproteinPrognosisROS, reactive oxygen speciesTBARS, thiobarbituric acid reacting substance

Identifiers

PMID24251116
PMCPMC3830063
OpenAlexW2035907631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.