ArticleFEBS open bio2013
Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats.
Article in FEBS open bio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Ketone Body β-Hydroxybutyrate Enhances Hypothalamic Leptin and Insulin Responsiveness.Nutrients · 2026Article
- Dopamine D2 receptor modulation of insulin receptor signaling in the central amygdala: implications for compulsive-like eating behavior.Molecular psychiatry · 2026Article
- Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake.International journal of molecular sciences · 2023Review
- Diet and obesity effects on cue-driven food-seeking: insights from studies of Pavlovian-instrumental transfer in rodents and humans.Frontiers in behavioral neuroscience · 2023Review
- Impaired insulin signalling and allostatic load in Alzheimer disease.Nature reviews. Neuroscience · 2022Review
- Mori Ramulus Inhibits Pancreatic β-Cell Apoptosis and Prevents Insulin Resistance by Restoring Hepatic Mitochondrial Function.Antioxidants (Basel, Switzerland) · 2021Article
- Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain.Antioxidants (Basel, Switzerland) · 2020Review
- Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding.JCI insight · 2020Article
- Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function.Frontiers in behavioral neuroscience · 2020Review
- Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients.JCI insight · 2019Article
- Scallop mantle extract inhibits insulin signaling in HepG2 cells.Food science & nutrition · 2019Article
- Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'.Journal of neuroscience methods · 2019Article
- Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity.Cell stress & chaperones · 2018Article
- Exendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells.Cell stress & chaperones · 2018Article
- Insulin Resistance in HIV-Patients: Causes and Consequences.Frontiers in endocrinology · 2018Review
- Neuropeptide Y expression marks partially differentiated β cells in mice and humans.JCI insight · 2017Article
- Insulin controls food intake and energy balance via NPY neurons.Molecular metabolism · 2017Article
- The Impact of Vitamin D Supplementation on Neurodegeneration, TNF-α Concentration in Hypothalamus, and CSF-to-Plasma Ratio of Insulin in High-Fat-Diet-Induced Obese Rats.Journal of molecular neuroscience : MN · 2017Article
- Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.American journal of physiology. Endocrinology and metabolism · 2016Review
- The role of endoplasmic reticulum stress in hippocampal insulin resistance.Experimental neurology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin acts in the hypothalamus, decreasing food intake (FI) by the IR/PI3K/Akt pathway. This pathway is impaired in obese animals and endoplasmic reticulum (ER) stress and low-grade inflammation are possible mechanisms involved in this impairment. Here, we highlighted the amygdala as an important brain region for FI regulation in response to insulin. This regulation was dependent on PI3K/AKT pathway similar to the hypothalamus. Insulin was able to decrease neuropeptide Y (NPY) and increase oxytocin mRNA levels in the amygdala via PI3K, which may contribute to hypophagia. Additionally, obese rats did not reduce FI in response to insulin and AKT phosphorylation was decreased in the amygdala, suggesting insulin resistance. Insulin resistance was associated with ER stress and low-grade inflammation in this brain region. The inhibition of ER stress with PBA reverses insulin action/signaling, decreases NPY and increases oxytocin mRNA levels in the amygdala from obese rats, suggesting that ER stress is probably one of the mechanisms that induce insulin resistance in the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.