ArticleMobile genetic elements2013
Domesticated transposable element gene products in human cancer.
Article in Mobile genetic elements, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
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- Discovery of a novel marker for human granulocytes and tissue macrophages: RTL1 revisited.Cell and tissue research · 2023Article
- Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.Oncology reports · 2019Article
- Article
- p53 in the game of transposons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Reverse transcriptase genes are highly abundant and transcriptionally active in marine plankton assemblages.The ISME journal · 2016Article
- Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon--derived family during mouse placentogenesis.Retrovirology · 2015Article
- Functional annotation of the Ophiostoma novo-ulmi genome: insights into the phytopathogenicity of the fungal agent of Dutch elm disease.Genome biology and evolution · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adaptation of transposable elements inserted within the genome to serve novel functions in a host cell, a process known as molecular domestication, is a widespread phenomenon in nature. Around fifty protein-coding genes in humans have arisen through this mechanism. Functional characterization of these domesticated genes has revealed involvement in a multitude of diverse cellular processes. Some of these functions are related to cellular activities and pathways known to be involved in cancer development. In this mini-review we discuss such roles of domesticated genes that may be aberrantly regulated in human cancer, as well as studies that have identified disrupted expression in tumors. We also describe studies that have provided definitive experimental evidence for transposable element-derived gene products in promoting tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.