ArticleJournal of cardiovascular and thoracic research2013
Effect of a Probiotic Preparation (VSL#3) on CardiovascularRisk Parameters in Critically-Ill Patients.
Article in Journal of cardiovascular and thoracic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials.Medicine · 2018Pooled it
- The use of probiotic L. fermentum ME-3 containing Reg'Activ Cholesterol supplement for 4 weeks has a positive influence on blood lipoprotein profiles and inflammatory cytokines: an open-label preliminary study.Nutrition journal · 2016Trial
- Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and antioxidant capacity biomarkers in women with polycystic ovary syndrome: A randomized placebo-controlled trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- The Effects of Probiotics Supplementation on Clinical Status and Biomarkers of Oxidative Damage and Inflammation in Children with Brucellosis: A Randomized, Double-Blind, and Placebo-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota.Journal of Korean medical science · 2021Article
- Postbiotics as novel health-promoting ingredients in functional foods.Health promotion perspectives · 2020Article
- Bile acids at the cross-roads of gut microbiome-host cardiometabolic interactions.Diabetology & metabolic syndrome · 2017Review
- Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE(-/-) mice.AMB Express · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCardiovascular disease (CVD) counts for a major portion of morbidity and mortality globally mostly accompanied by lipid abnormalities. Being at increased risk of cardiac injury, critically ill patients suffer from various lipid disorders. Lipid homeostasis has been efficiently restored by the introduction of probiotics. The aim of this trial was to determine the effect of probiotics on inflammation, antioxidant capacity and lipid peroxidation in critically ill patients.
methodsForty patients admitted to the intensive care unit were randomized to receive placebo or probiotic for 7 days. Serum levels of triglyceride (TG), total cholesterol, HDL-C, LDL-C and high- sensitivity C-reactive protein (hs-CRP) were measured before initiation of the study and on the 7(th) day.
resultsThere was a significant difference between two groups regarding the levels of TG, HDL and hs-CRP at the end of the study (P= 0.043, <0.001 and 0.003, respectively); however, there was not a significant difference in total cholesterol and LDL-C levels.
conclusionAdministration of probiotics in critically ill patients reduced the levels of TG and hs-CRP and increased HDL-C levels. However, no significant change was detected in levels of total cholesterol or LDL-C.
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