ArticleIranian journal of pharmaceutical research : IJPR2013
Carbapenem Restriction and its Effect on Bacterial Resistance in an Intensive Care unit of a Teaching Hospital.
Article in Iranian journal of pharmaceutical research : IJPR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Clinical and economic impacts of clinical pharmacists' interventions in Iran: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Pooled it
- Antimicrobial stewardship of Chinese ministry of health reduces multidrug-resistant organism isolates in critically ill patients: a pre-post study from a single center.BMC infectious diseases · 2016Trial
- Impact of COVID-19 Pandemic on Antibiotic Resistance Patterns of Common Bacterial Pathogens to Antibiotics in Northern Ghana.Journal of clinical laboratory analysis · 2026Article
- High heterogeneity of fecal carriage extended-spectrum beta-lactamase-producing E. coli isolated from iranian community and clinical settings.BMC infectious diseases · 2022Article
- The Effect of Antibiotic Restriction Programs on Prevalence of Antimicrobial Resistance: A Systematic Review and Meta-Analysis.Open forum infectious diseases · 2021Article
- Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes inInfection and drug resistance · 2021Article
- Conjunctival bacterial flora and antimicrobial susceptibility in bacterial pathogens isolated prior to cataract surgery.Japanese journal of ophthalmology · 2020Article
- Characterization of aminoglycoside resistance mechanisms in Acinetobacter Baumannii isolates from burn wound colonization.Annals of burns and fire disasters · 2019Article
- Antibiotic Prescribing Trends Before and After Implementation of an Audit and Feedback Program in Internal Ward of a Tertiary Hospital in Tehran.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Introducing an antibiotic stewardship program in a pediatric center in China.World journal of pediatrics : WJP · 2018Article
- Interim Study: Comparison Of Safety And Efficacy of Levofloxacin Plus Colistin Regimen With Levofloxacin Plus High Dose Ampicillin/Sulbactam Infusion In Treatment of Ventilator-Associated Pneumonia Due To Multi Drug Resistant Acinetobacter.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Evaluating the resistance pattern of gram-negative bacteria during three years at the nephrology ward of a referral hospital in southwest of Iran.Journal of nephropathology · 2017Article
- Synthesis and Evaluation of the Antimicrobial Activity of Spiro-4H-pyran Derivatives on Some Gram Positive and Gram Negative Bacteria.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Once Versus Thrice Daily Colistin in Critically Ill Ptients with Multi-Drug Resistant Infections.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Effects of an antimicrobial restriction system on appropriate carbapenem use in a hospital without infectious diseases consultation.International journal of general medicine · 2017Article
- Prevalence and Etiology of Bacteremia in Febrile Children with Sickle Cell Disease at a Nigeria Tertiary Hospital.Mediterranean journal of hematology and infectious diseases · 2017Article
- Antibiotic stewardship programmes in intensive care units: Why, how, and where are they leading us.World journal of critical care medicine · 2015Review
- Effects of Pharmacist Intervention on the Utilization of Vancomycin in a Teaching Hospital.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Wide distribution of carbapenem resistant Acinetobacter baumannii in burns patients in Iran.Frontiers in microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDevelopment of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Carbapenem prescription in ICU1 was restricted to only the culture proven multi-drug-resistant bacteria with the absence of sensitivity to other antimicrobial agents. Carbapenem had to be prescribed by a trained ICU physician with close consultation with infectious disease specialist and the clinical pharmacist posted in ICU. Post-prescription reviews and de-escalations were carried out by the same team on regular basis. Restriction policy was commenced in January 2011 in ICU1. All documented infections and resistance patterns of isolated pathogens were recorded in both ICUs during two periods of 6 months before and 9 months after restriction policy implementation. During this study bacterial growth was detected in 51.5% of 1601 samples. Carbapenem administration was decreased from 6.86 to 2.75 DDD/100 patients day (60% decreases) pre-restriction and post-restriction respectively. Significant increase in sensitivity of pseudomonas to imipenem was observed in ICU1 comparing with pre-restriction period six months post restriction (p = 0.000). Sensitivity of Klebsiella and Acinetobacter to imipenem did not change significantly during the study period.
conclusionOur study demonstrated that restriction of carbapenems can increase sensitivity of P. aeroginosa to imipenem.
Identifiers
24250656PMC3813286W2141547157What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.