ArticleIranian journal of pharmaceutical research : IJPR2013
Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line.
Article in Iranian journal of pharmaceutical research : IJPR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Sustainable Applications of Thymol: Advances in Formulation Technologies, Drug Delivery Systems, and Food Preservation Strategies.Food science & nutrition · 2026Review
- Cytotoxic and apoptotic effects of Ferula gummosa Boiss: extract on human breast adenocarcinoma cell line.Molecular biology reports · 2024Article
- Sesquiterpenes and Sesquiterpene Derivatives fromAntioxidants (Basel, Switzerland) · 2023Review
- Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots ofMolecules (Basel, Switzerland) · 2023Article
- Review
- Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin.Biomedicines · 2020Review
- Article
- Antitumor Effects of Umbelliprenin in a Mouse Model of Colorectal Cancer.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Phytochemistry and pharmacology ofIranian journal of basic medical sciences · 2017Review
- Evaluating cytotoxic effect of nanoliposomes encapsulated with umbelliprenin on 4T1 cell line.In vitro cellular & developmental biology. Animal · 2017Article
- Umbelliprenin is Potentially Toxic Against the HT29, CT26, MCF-7, 4T1, A172, and GL26 Cell Lines, Potentially Harmful Against Bone Marrow-Derived Stem Cells, and Non-Toxic Against Peripheral Blood Mononuclear Cells.Iranian Red Crescent medical journal · 2016Article
- Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes.Avicenna journal of phytomedicine · 2014Article
- Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Mcl-1 is up regulated by prenylated coumarin, umbelliprenin in jurkat cells.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Umbelliprenin, a bioactive constituent from the genusAvicenna journal of phytomedicineArticle
- Cytotoxic activity of the genusAvicenna journal of phytomedicineReview
- Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antiapoptotic Bcl-2 family protein was studied. Jurkat cells were incubated with umbelliprenin. Cells were then lysed and activation of proteins was studied by Western blot analysis. In this study, we showed that umbelliprenin activates intrinsic and extrinsic pathways of apoptosis by the activation of caspase-8 and -9 respectively. Inhibition of Bcl-2 was also shown. In conclusion, umbelliprenin induced apoptosis in Jurkat cells through caspase-dependent apoptosis pathway.
Indexed as
Identifiers
24250644PMC3813267W2269612035What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.