ArticleIranian journal of pharmaceutical research : IJPR2013
Evaluation of the antibacterial activity of patchouli oil.
Article in Iranian journal of pharmaceutical research : IJPR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Patchouli Alcohol as a Potential Anti-Cariogenic Compound TargetingMolecules (Basel, Switzerland) · 2026Article
- Alpha-guaiene isolated from patchouli oil exhibits antifungal activity against four pathogenic fungi.F1000Research · 2025Article
- The Flow Rate of the Condenser Cooling Water in the Distillation Process Increases the Quality and Quantity of Patchouli Oil.TheScientificWorldJournal · 2024Article
- Activity of Patchouli and Tea Tree Essential Oils against Staphylococci Isolated from Pyoderma in Dogs and Their Synergistic Potential with Gentamicin and Enrofloxacin.Animals : an open access journal from MDPI · 2023Article
- Biofabrication of Silver Nanoparticles UsingInternational journal of nanomedicine · 2023Article
- Characterization of Bioactive Compounds from Patchouli Extracted via Supercritical Carbon Dioxide (SC-COMolecules (Basel, Switzerland) · 2022Article
- Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel.Gels (Basel, Switzerland) · 2022Article
- GC-MS analysis and molecular docking of bioactive compounds of Camellia sinensis and Camellia assamica.Archives of microbiology · 2021Article
- Inhalation of Patchouli (Nutrients · 2020Article
- Potentials of patchouli (Pogostemon cablin) essential oil on ruminal methanogenesis, feed degradability, and enzyme activities in vitro.Environmental science and pollution research international · 2019Article
- Evaluation of the Larvicidal Potential of the Essential OilPharmaceuticals (Basel, Switzerland) · 2019Article
- Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats.Experimental and therapeutic medicine · 2017Article
- Availability, Pharmaceutics, Security, Pharmacokinetics, and Pharmacological Activities of Patchouli Alcohol.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- In vitro antibacterial activity of selected medicinal plants traditionally used in Vietnam against human pathogenic bacteria.BMC complementary and alternative medicine · 2016Article
- The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 CellsBioMed research international · 2016Article
- A Comprehensive Review on the Phytochemical Constituents and Pharmacological Activities of Pogostemon cablin Benth.: An Aromatic Medicinal Plant of Industrial Importance.Molecules (Basel, Switzerland) · 2015Review
- A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Characterization of ambrette seed oil and its mode of action in bacteria.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the antimicrobial tests of patchouli oil were studied by using molecular docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as target molecules. Five antibiotics benzylpenicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, which are generally acknowledged as antibacterial drugs, were selected as reference compounds. The 3 three-dimensional (3D) structures of the 5 reference compounds and 26 compounds from patchouli oil were established by using surflex-dock software (8.1). And the 3D structures of five biological macromolecule enzymes derived from Protein Data Bank (PDB). Molecular docking was carried out between the 31 chemical compounds (ligands) and the 5 enzymes (receptors) by using surflex-dock function. Furthermore, the antibacterial effects of 31 chemical compounds were investigated by the scoring function after molecular docking was completed. By comparing the scoring result of 26 compounds in patchouli oil with 5 compared components, we inferred antibacterial activity in about 26 compounds in patchouli oil. On the other hand, six frequently-used pathogenic bacteria were selected for antimicrobial test in vitro, patchouli oil and its two major compounds: (-)-patchouli alcohol and pogostone, which their contents exceeded 60% in patchouli oil samples, were selected antibacterial agents. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) were also determined. Molecular docking technology and antimicrobial test in vitro proved that patchouli oil had strong antimicrobial effects. Particularly, pogostone and (-)-patchouli alcohol have potent antimicrobial activity.
Indexed as
Identifiers
24250637PMC3813264W2230710181What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.