ArticleIranian journal of pharmaceutical research : IJPR2012
Umbelliprenin Induces Apoptosis in CLL Cell Lines.
Article in Iranian journal of pharmaceutical research : IJPR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Joining up the scattered anticancer knowledge on auraptene and umbelliprenin: a meta-analysis.Scientific reports · 2024Pooled it
- Cytotoxic and apoptotic effects of Ferula gummosa Boiss: extract on human breast adenocarcinoma cell line.Molecular biology reports · 2024Article
- Sesquiterpenes and Sesquiterpene Derivatives fromAntioxidants (Basel, Switzerland) · 2023Review
- Anticancer potential ofWorld journal of biological chemistry · 2023Review
- Review
- Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin.Biomedicines · 2020Review
- Article
- Medicinal Plants from Near East for Cancer Therapy.Frontiers in pharmacology · 2018Review
- Umbelliprenin induced both anti-inflammatory and regulatory cytokines in C57/BL6 mice.Iranian journal of basic medical sciences · 2017Article
- Letter to the Editor.Journal of evidence-based complementary & alternative medicine · 2017Article
- Evaluating cytotoxic effect of nanoliposomes encapsulated with umbelliprenin on 4T1 cell line.In vitro cellular & developmental biology. Animal · 2017Article
- Phytochemistry and pharmacology ofIranian journal of basic medical sciences · 2017Review
- Umbelliprenin is Potentially Toxic Against the HT29, CT26, MCF-7, 4T1, A172, and GL26 Cell Lines, Potentially Harmful Against Bone Marrow-Derived Stem Cells, and Non-Toxic Against Peripheral Blood Mononuclear Cells.Iranian Red Crescent medical journal · 2016Article
- Mcl-1 is up regulated by prenylated coumarin, umbelliprenin in jurkat cells.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Umbelliprenin, a bioactive constituent from the genusAvicenna journal of phytomedicineArticle
- Cytotoxic activity of the genusAvicenna journal of phytomedicineReview
- Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary.Dose-response : a publication of International Hormesis SocietyArticle
- Pharmacological and phytochemical appraisal of selected medicinal plants from jordan with claimed antidiabetic activities.Scientia pharmaceuticaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines. In this study induction of apoptosis by umbelliprenin on Jurkat T-CLL and Raji B-CLL cell lines was studied. In this regard, cells were incubated with various concentrations of umbelliprenin in-vitro for different times and assayed for apoptosis with annexin V-FITC/PI double staining flowcytometry method. Results showed that umbelliprenin induced apoptosis in leukemic cells in a dose- and time-dependent manner and that CLL cells were more susceptible to umbelliprenin induced cell death than normal peripheral blood mononuclear cell (PBMCs). Moreover, we study the induction of apoptosis in Jurkat cells by umbelliprenin in the presence of interleukin 4 (IL-4) as an agent that causes resistance to apoptosis in CLL cells, was also student. We showed that IL-4 can not reduce apoptotic effect of umbelliprenin. The preferential toxicity of umbelliprenin for CLL cells, supports the hypothesis that oral administration of umbelliprenin in the form of foods or folk medicines containing this coumarin, might enhance protection against the development of CLL in man with little side effects. In conclusion, umbelliprenin may be an effective therapeutic agent in the treatment of CLL, and thus clinical studies with umbelliprenin may be appropriate.
Indexed as
Identifiers
24250490PMC3832171W2134921227What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.