ArticleIranian journal of pharmaceutical research : IJPR2012
A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches.
Article in Iranian journal of pharmaceutical research : IJPR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- A proprietary blend of standardizedInternational journal of medical sciences · 2022Trial
- A Traditional Mouthwash (Punica granatum var pleniflora) for Controlling Gingivitis of Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial.Journal of evidence-based complementary & alternative medicine · 2017Trial
- Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containingDrug design, development and therapy · 2017Trial
- Efficacy and acceptability of pomegranate effervescent granules in patients suffering from acid peptic disorders.Indian journal of pharmacologyTrial
- The Versatility of Pomegranate: From Phytochemical Diversity to Antimicrobial and Translational Applications.Microorganisms · 2026Review
- A novel approach for phyto-synthesis of silver nanoparticles using floral extract of Punica granatum for potent anti-cancerous and antibacterial capabilities.Discover nano · 2025Article
- Effects of Pomegranate Juice on Androgen Levels, Inflammation and Lipid Profile in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The Role of Pomegranate (Food science & nutrition · 2025Review
- In-vitro scientific validation of anti-inflammatory activity ofAfrican health sciences · 2024Article
- Antiangiogenic Potential of Pomegranate Extracts.Plants (Basel, Switzerland) · 2024Review
- In-vitro scientific validation of anti-inflammatory activity ofAfrican health sciences · 2024Article
- Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Review
- Developmental landscape of computational techniques to explore the potential phytochemicals fromFrontiers in molecular biosciences · 2023Article
- The Therapeutic Efficacy ofPlants (Basel, Switzerland) · 2022Review
- Pomegranate Peel as a Source of Bioactive Compounds: A Mini Review on Their Physiological Functions.Frontiers in nutrition · 2022Review
- Toxicological Assessments of a Proprietary Blend ofJournal of toxicology · 2022Article
- Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells.Journal of traditional and complementary medicine · 2022Article
- Jabuticaba (Molecules (Basel, Switzerland) · 2021Article
- Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. They also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and vital enzymes such as cyclooxygenase (COX), lipooxygenase (LOX), cytochrome P450 (CYP450), phospholipase A2 (PLA2), ornithine decarboxylase (ODC), carbonic anhydrase (CA), 17beta-hydroxysteroid dehydrogenase (17β-HSDs) and serine protease (SP). Furthermore, they can stimulate cell differentiation and possess anti-mutagenic effects. Pg can also interfere with several signaling pathways including PI3K/AKT, mTOR, PI3K, Bcl-X, Bax, Bad, MAPK, ERK1/2, P38, JNK, and caspase. However, the exact mechanisms for its pharmacological and toxicological properties remain to be unclear and need further evaluation. These properties strongly suggest a wide range use of Pg for clinical applications. This review will discuss the areas for which Pg has shown therapeutic properties in different mechanisms.
Indexed as
Identifiers
24250463PMC3832175What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.