ArticleIranian journal of pharmaceutical research : IJPR2011
Pentacyclic Triterpenes in Euphorbia microsciadia with Their T-cell Proliferation Activity.
Article in Iranian journal of pharmaceutical research : IJPR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants.Molecules (Basel, Switzerland) · 2024Pooled it
- Evaluation of the Neuroprotective Effects of Diospyros discolor and Diospyros ebenum Leaf Bioactive Fractions In Vivo and Their UPLC-ESI-MS/MS Chemical Characterization: A Comparative Study.Journal of food science · 2026Article
- Isolation, purification and characterization of betulinic acid derivative from the root bark ofInternational journal of biochemistry and molecular biology · 2026Article
- Insight into Cytotoxic Potential ofPlants (Basel, Switzerland) · 2025Article
- Metabolic profiling of Vitex Pubescens Vahl bark via UPLC-ESI-QTOF/MS/MS analysis and evaluation of its antioxidant and acetylcholinesterase inhibitory activities.BMC complementary medicine and therapies · 2024Article
- Article
- UPLC-ESI-MS/MS Profiling and Cytotoxic, Antioxidant, Anti-Inflammatory, Antidiabetic, and Antiobesity Activities of the Non-Polar Fractions ofPlants (Basel, Switzerland) · 2023Article
- Comparative metabolic profiling of olive leaf extracts from twelve different cultivars collected in both fruiting and flowering seasons.Scientific reports · 2023Article
- Metabolic profiling of Lantana camara L. using UPLC-MS/MS and revealing its inflammation-related targets using network pharmacology-based and molecular docking analyses.Scientific reports · 2022Article
- Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking.Journal of ethnopharmacology · 2022Article
- Isolation, Structure Elucidation and Antimicrobial Evaluation of Natural Pentacyclic Triterpenoids and Phytochemical Investigation of Different Fractions ofMolecules (Basel, Switzerland) · 2022Article
- Anticancer Potential of Betulonic Acid Derivatives.International journal of molecular sciences · 2021Review
- A new sesquiterpenoid from the shoots of Iranian Daphne mucronata Royle with selective inhibition of STAT3 and Smad3/4 cancer-related signaling pathways.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Beneficial effect of standardized extracts ofHeliyon · 2020Article
- Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review.Chinese herbal medicines · 2020Review
- Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family.Scientific reports · 2019Article
- Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds fromAdvances in pharmacological sciences · 2019Article
- Immunomodulatory activities of isolated compounds from the root-bark of Cussonia arborea.Pharmaceutical biology · 2017Article
- Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera.Bioorganic & medicinal chemistry · 2016Article
- Triterpene Constituents ofIranian journal of pharmaceutical research : IJPR · 2016Article
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Authors and funding
6 authors.
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Abstract
The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass fragmentation pattern, nuclear magnetic resonance (NMR) data and their biologic immunomodulatory effects. The structures of the isolated compounds were elucidated by (13)C- and (1)H-NMR as well as 2D-NMR, IR and by the aid of mass fragmentation pattern and comparing with the literature. After running T-Cell proliferation assay, oleanolic acid stimulated proliferation of T-Cells at lower concentration 0.5 µg/mL, while betulinic acid and ursolic acid showed inhibitory activity against T-Cell proliferation with IC50- value > 50 µg/mL and 3.01 ± 0.47 µg/mL, respectively.
Indexed as
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24250356PMC3828914What OpenQuestion holds
Registered trials
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