ArticleThe Journal of experimental medicine1986
Functional study of a monoclonal antibody to IgE Fc receptor (Fc epsilon R2) of eosinophils, platelets, and macrophages.
Article in The Journal of experimental medicine, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 152 citations in OpenAlex.
- Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer.Frontiers in oncology · 2022Review
- Review
- Modulation of Immune Responses by Platelet-Derived ADAM10.Frontiers in immunology · 2020Review
- Granulocytes in helminth infection -- who is calling the shots?Current medicinal chemistry · 2012Review
- Platelet activation during allergic inflammation.Inflammation · 2007Review
- Anti-CD23.Clinical reviews in allergy & immunology · 2005Review
- A microfilament formation inhibitor, cytochalasin strongly enhances the low-affinity Fc epsilon receptor II (CD23) expression on the human monocyte-like cell line, U937.Journal of clinical immunology · 2000Article
- Role of IgE immune complexes in the regulation of HIV-1 replication and increased cell death of infected U1 monocytes: involvement of CD23/Fc epsilon RII-mediated nitric oxide and cyclic AMP pathways.Molecular medicine (Cambridge, Mass.) · 1996Article
- Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation.The Journal of clinical investigation · 1995Article
- Eosinophils in the 1990s: new perspectives on their role in health and disease.Postgraduate medical journal · 1994Review
- Article
- CD23 antigen regulation and signaling in chronic lymphocytic leukemia.The Journal of clinical investigation · 1992Article
- Eosinophil IgE receptor and CD23.Immunologic research · 1992Review
- Sputum eosinophils from asthmatics express ICAM-1 and HLA-DR.Clinical and experimental immunology · 1991Article
- Dermatology.Postgraduate medical journal · 1990Review
- Release of leukotriene C4 (LTC4) from human eosinophils following adherence to IgE- and IgG-coated schistosomula of Schistosoma mansoni.Immunology · 1990Article
- The IgE receptor of eosinophils.Springer seminars in immunopathology · 1990Review
- Fc epsilon receptor II-positive macrophages and platelets: potent effector cells in allergy and defence against helminth parasites.Springer seminars in immunopathology · 1990Review
- The receptor for the Fc region of IgE.Springer seminars in immunopathology · 1990Review
- Stimulation of connective tissue-type mast cell proliferation by crosslinking of cell-bound IgE.The Journal of experimental medicine · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An IgM mAb (BB10) was produced by immunization of mice with human eosinophils purified according to their abnormal low density ("hypodense" cells), and previously shown to exhibit increased IgE-dependent antiparasite cytotoxicity. This BB10 antibody, selected for positive fluorescence staining of hypodense blood or lung eosinophils and low or negative staining of normodense eosinophils or neutrophils, could strongly inhibit IgE-dependent cytotoxicity of human eosinophils and platelets. The specificity for the IgE Fc receptor was suggested by the high levels of inhibition of IgE rosettes formed by eosinophils after incubation with the purified IgM fraction of BB10, whereas other receptors (Fc gamma R, CR1) were not affected. On the other hand, BB10, able to inhibit rat eosinophil Fc epsilon R, did not react with the IgE Fc receptor on mast cells or basophils. A technique using radioiodinated BB10 allowed us to quantify the specific binding of BB10 to human eosinophils and platelets. Competition experiments revealed a crossinhibition between the binding of BB10 and IgE, suggesting the specificity of BB10 for the IgE binding site of eosinophil, platelet, and monocyte Fc epsilon R. Three proteins having extrapolated Mr of 32,000, 43,000-45,000, and 97,000 were found in the platelet extract eluted from a BB10 or from an IgE immunosorbent column. These findings confirm the similarities between IgE Fc receptors on human eosinophils, platelets, and macrophages, already observed with polyclonal antibodies directed against the B lymphocyte Fc epsilon receptor. They suggest, moreover, that the mAb BB10 can represent a good reagent for further investigations on the structure and the functions of this IgE Fc receptor (Fc epsilon R2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.