The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

1. A comprehensive review of alkaloids in cancer therapy: focusing on molecular mechanisms and synergistic potential of piperine in colorectal cancer.3 Biotech · 2025
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2. Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management.Molecules (Basel, Switzerland) · 2023
   Review
3. Re-Sensitizing Cancer Stem Cells to Conventional Chemotherapy Agents.International journal of molecular sciences · 2023
   Review
4. Tumor microenvironment pathways: Cross regulation in breast cancer metastasis.Genes & diseases · 2022
   Review
5. Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products.Frontiers in pharmacology · 2022
   Review
6. Eggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance.Biomedicines · 2021
   Article
7. The Role of Smoothened in Cancer.International journal of molecular sciences · 2020
   Review
8. The double edge sword of fibrosis in cancer.Translational research : the journal of laboratory and clinical medicine · 2019
   Review
9. Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics.Cells · 2019
   Review
10. The "Yin and Yang" of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers.Cancers · 2018
    Review
11. Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer.International journal of molecular sciences · 2018
    Article
12. Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma.Cancer cell international · 2017
    Article
13. Isocyclopamine, a novel synthetic derivative of cyclopamine, reverts doxorubicin resistance in MCF-7/ADR cells by increasing intracellular doxorubicin accumulation and downregulating breast cancer stem-like cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
14. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.Seminars in cancer biology · 2015
    Review
15. The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis.Cancers · 2015
    Review
16. New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers.World journal of clinical cases · 2014
    Review
17. Cancer stem cells as a potential therapeutic target in breast cancer.Stem cell investigation · 2014
    Review
18. Patched targeting peptides for imaging and treatment of hedgehog positive breast tumors.BioMed research international · 2014
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

7 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as