ReviewMediators of inflammation2013
Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge.
Review in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04884854 (Early Efferon LPS Hemoperfusion Through Hypercrosslinked Styrene-divinylbenzene Copolymer With Immobilized LPS-selective Ligand for Treatment of Patients With Septic Shock), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Efferon LPS Hemoperfusion Through Hypercrosslinked Styrene-divinylbenzene Copolymer With Immobilized LPS-selective Ligand for Treatment of Patients With Septic Shock
Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Extracorporeal Cytokine Hemadsorption with oXirisJournal of clinical medicine · 2026Article
- A peptide-based medical device for the selective removal of inflammatory factors from the blood of people with sepsis.Communications medicine · 2025Article
- Diagnostic Accuracy of Endotoxin and Endotoxin Binding Protein in Late-Onset Neonatal Sepsis.Indian journal of pediatrics · 2025Article
- Autologous cryo-shocked neutrophils enable targeted therapy of sepsis via broad-spectrum neutralization of pro-inflammatory cytokines and endotoxins.Frontiers in chemistry · 2024Article
- Investigation of Endotoxin Positivity in Ascites at the Time of Cell-free and Concentrated Ascites Re-infusion Therapy.Internal medicine (Tokyo, Japan) · 2023Article
- Increased Endotoxin Activity in COVID-19 Patients Admitted to the Intensive Care Unit.Journal of intensive care medicine · 2023Article
- Mitochondrial DNA as a Candidate Marker of Multiple Organ Failure after Cardiac Surgery.International journal of molecular sciences · 2022Article
- Potential survival benefit and early recovery from organ dysfunction with polymyxin B hemoperfusion: perspectives from a real-world big data analysis and the supporting mechanisms of action.Journal of anesthesia, analgesia and critical care · 2022Review
- Interaction of Lipopolysaccharide-Spiked Blood with Anti-Fouling Polymyxin B-Modified Glass.Materials (Basel, Switzerland) · 2022Article
- Hemoadsorption in the critically ill-Final results of the International CytoSorb Registry.PloS one · 2022Article
- Self-assembled raccoon dog parvovirus VP2 protein confers immunity against RDPV disease in raccoon dogs: in vitro and in vivo studies.Virology journal · 2021Article
- The application value of oXiris-endotoxin adsorption in sepsis.American journal of translational research · 2021Article
- Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats.Acta cirurgica brasileira · 2020Article
- International registry on the use of the CytoSorb® adsorber in ICU patients : Study protocol and preliminary results.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2019Review
- Bioassay for Endothelial Damage Mediators Retrieved by Hemoadsorption.Scientific reports · 2019Article
- Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system.Journal of cardiac surgery · 2019Article
- Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats.Journal of inflammation research · 2019Article
- Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis.Frontiers in immunology · 2019Review
- Impact of hemoperfusion with polymyxin B added to hemofiltration in patients with endotoxic shock: a case-control study.Annals of intensive care · 2018Article
- Successful use of combined blood purification techniques in splenectomised patient with septic shock in streptococcus pneumoniae infection - a case report.BMC infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells. Removal of endotoxin could be an effective adjunctive approach to the management of sepsis. Devices to adsorb endotoxin or inflammatory cytokines have been designed as a strategy to treat severe sepsis, especially sepsis caused by gram-negative bacteria. Polymyxin B-immobilized cartridge has been successfully used to treat patients with sepsis of abdominal origin. Although this cartridge was conceived to adsorb endotoxin, several other immunological mechanisms have been elucidated, and this device has also yielded promising results in patients with nonseptic respiratory failure. In this paper, we summarize the immune modulation actions of Polymyxin B-immobilized cartridge to explore its potential usefulness beyond endotoxin elimination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.