ArticleJournal of clinical biochemistry and nutrition2013
Multicomponent supplement containing Chlorella decreases arterial stiffness in healthy young men.
Article in Journal of clinical biochemistry and nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis.Nutrition & diabetes · 2026Pooled it
- Edible Algae Reduce Blood Pressure in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Pooled it
- Effects ofInternational journal of environmental research and public health · 2020Trial
- Biotechnological Approaches for Biomass and Lipid Production Using MicroalgaeJournal of microbiology and biotechnology · 2022Review
- Algae Supplementation for Exercise Performance: Current Perspectives and Future Directions for Spirulina and Chlorella.Frontiers in nutrition · 2022Article
- Potential ofNutrients · 2020Review
- Combined aerobic and low-intensity resistance exercise training increases basal nitric oxide production and decreases arterial stiffness in healthy older adults.Journal of clinical biochemistry and nutrition · 2020Article
- Changes in salivary flow rate following Chlorella-derived multicomponent supplementation.Journal of clinical biochemistry and nutrition · 2016Article
- Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals.Journal of clinical biochemistry and nutrition · 2015Article
- Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals.Journal of clinical biochemistry and nutrition · 2015Article
- The use of Piper sarmentosum leaves aqueous extract (Kadukmy™) as antihypertensive agent in spontaneous hypertensive rats.BMC complementary and alternative medicine · 2015Article
- Chlorella-derived multicomponent supplementation increases aerobic endurance capacity in young individuals.Journal of clinical biochemistry and nutrition · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorella, a unicellular green alga, contains various antioxidants and other nutrients such as amino acids and fiber. Previous studies have reported that supplementation with multiple antioxidants reduces arterial stiffness, a well-established cardiovascular risk factor. We investigated the effects of Chlorella intake on arterial stiffness using a single-blinded, placebo-controlled crossover study design. Fourteen young men took placebo or Chlorella tablets for four weeks, with a 12-week washout period between trials, in a randomized order. Before and after each trial, blood pressure, heart rate, and brachial-ankle pulse wave velocity, an index of arterial stiffness, were measured. Treatment compliance was comparable between the two groups. There were no differences in blood pressure and heart rate before and after supplementation in both the placebo and Chlorella groups. Brachial-ankle pulse wave velocity decreased after Chlorella intake (before vs after intake; 11.6 ± 0.2 vs 11.1 ± 0.1 m/s, p = 0.01), but not after placebo intake (11.4 ± 0.2 vs 11.4 ± 0.2 m/s, p = 0.98). Multicomponent analysis of the Chlorella-containing tablet detected nutrients that can reduce arterial stiffness, such as antioxidant vitamins, arginine, potassium, calcium, and n-3 unsaturated fatty acids. These results suggest that intake of a Chlorella-containing multicomponent supplement can decrease arterial stiffness.
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Registered trials
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