ArticleThe Plant cell2013
Plastid-localized glutathione reductase2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Polyploidy and zinc nanoparticles enhanced cadmium tolerance by regulating antioxidants and transport proteins.Plant cell reports · 2026Article
- AtCHE1, the Arabidopsis homolog of mammalian AATF/Che-1 protein, is involved in safeguarding genome stability.Communications biology · 2025Article
- Dynamic regulation of Arabidopsis β-AMYLASE1 by glutathione and thioredoxins affects starch in guard cells.Plant physiology · 2025Article
- Turning the knobs: The impact of glutathionylation on starch metabolism.Plant physiology · 2025Article
- Map-based cloning of Zmccr3 and its network construction and validation for regulating maize seed germination.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- SYNTAXIN OF PLANTS132 Regulates Root Meristem Activity and Stem Cell Niche Maintenance via RGF-PLT Pathways.International journal of molecular sciences · 2025Article
- Divergent roles of ADP-ribosylation factor GTPase-activating proteins in lignocellulose utilization of Trichoderma guizhouense NJAU4742.Biotechnology for biofuels and bioproducts · 2024Article
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
- Hydrogen Peroxide Signaling in the Maintenance of Plant Root Apical Meristem Activity.Antioxidants (Basel, Switzerland) · 2024Review
- Chloroplasts lacking class I glutaredoxins are functional but show a delayed recovery of protein cysteinyl redox state after oxidative challenge.Redox biology · 2024Article
- Comprehensive characterization and expression analysis of enzymatic antioxidant gene families in passion fruit (iScience · 2023Article
- ROS-stimulated protein lysine acetylation is required for crown root development in rice.Journal of advanced research · 2023Article
- Proteasome Dysfunction Leads to Suppression of the Hypoxic Response Pathway in Arabidopsis.International journal of molecular sciences · 2022Article
- Non-volatile signals and redox mechanisms are required for the responses of Arabidopsis roots to Pseudomonas oryzihabitans.Journal of experimental botany · 2022Article
- Proline Affects Flowering Time in Arabidopsis by Modulating FLC Expression: A Clue of Epigenetic Regulation?Plants (Basel, Switzerland) · 2022Article
- A plastidial retrograde signal potentiates biosynthesis of systemic stress response activators.The New phytologist · 2022Article
- Reactive Oxygen Species, Antioxidant Responses and Implications from a Microbial Modulation Perspective.Biology · 2022Review
- Microbe-Mediated Thermotolerance in Plants and Pertinent Mechanisms- A Meta-Analysis and Review.Frontiers in microbiology · 2022Review
- Mechanisms of stress response in the root stem cell niche.Journal of experimental botany · 2021Review
- Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification.Metabolites · 2021Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione is involved in thiol redox signaling and acts as a major redox buffer against reactive oxygen species, helping to maintain a reducing environment in vivo. Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide (GSSG) into reduced glutathione (GSH). The Arabidopsis thaliana genome encodes two GRs: GR1 and GR2. Whereas the cytosolic/peroxisomal GR1 is not crucial for plant development, we show here that the plastid-localized GR2 is essential for root growth and root apical meristem (RAM) maintenance. We identify a GR2 mutant, miao, that displays strong inhibition of root growth and severe defects in the RAM, with GR activity being reduced to ∼50%. miao accumulates high levels of GSSG and exhibits increased glutathione oxidation. The exogenous application of GSH or the thiol-reducing agent DTT can rescue the root phenotype of miao, demonstrating that the RAM defects in miao are triggered by glutathione oxidation. Our in silico analysis of public microarray data shows that auxin and glutathione redox signaling generally act independently at the transcriptional level. We propose that glutathione redox status is essential for RAM maintenance through both auxin/PLETHORA (PLT)-dependent and auxin/PLT-independent redox signaling pathways.
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