SynthesisArchives of disease in childhood. Fetal and neonatal edition2014
Definitions of extubation success in very premature infants: a systematic review.
Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.The Cochrane database of systematic reviews · 2024Pooled it
- Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in newborn infants.The Cochrane database of systematic reviews · 2016Pooled it
- [Safety of two ventilator weaning strategies after high-frequency oscillatory ventilation in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- Comparison of extubation success using noninvasive positive pressure ventilation (NIPPV) versus noninvasive neurally adjusted ventilatory assist (NI-NAVA).Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Transcervical Epiglottic Suspension for Severe Type III Laryngomalacia in Infants: Feasibility, Safety, and Effectiveness.Laryngoscope investigative otolaryngology · 2026Article
- Nomogram-based prediction model for extubation failure in preterm infants with invasive mechanical ventilation.Italian journal of pediatrics · 2025Article
- Sonographic evaluation of lungs and diaphragm as a predictor for extubation failure in early preterm neonates: a prospective diagnostic accuracy study.European journal of pediatrics · 2025Article
- The Effect on Extubation of Early vs. Late Definitive Closure of the Patent Ductus Arteriosus in Premature Infants: A Target Trial Emulation Using Electronic Health Records.Journal of clinical medicine · 2025Article
- Risk factors and adverse outcomes of extubation failure in preterm infants ≤32 weeks with neonatal respiratory distress syndrome.Frontiers in pediatrics · 2025Article
- Respiratory outcomes and survival after unplanned extubation in the NICU: a prospective cohort study from the SEPREVEN trial.Archives of disease in childhood. Fetal and neonatal edition · 2024Observational
- Predicting Extubation Readiness in Preterm Infants Utilizing Machine Learning: A Diagnostic Utility Study.The Journal of pediatrics · 2024Observational
- Article
- Predictors of successful extubation from volume-targeted ventilation in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Dexamethasone Use to Reduce Mechanical Ventilation and Bronchopulmonary Dysplasia in the Neonatal Intensive Care Unit.The Canadian journal of hospital pharmacy · 2024Article
- Feasibility of Endotracheal Extubation Evaluation Form in Predicting Successful Extubation in Neonatal Intensive Care Units: A Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Automated prediction of extubation success in extremely preterm infants: the APEX multicenter study.Pediatric research · 2023Article
- Prediction of extubation failure among low birthweight neonates using machine learning.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Risk factors and clinical outcomes of extubation failure in very early preterm infants: a single-center cohort study.BMC pediatrics · 2023Article
- Predictive factors for extubation success in very low and extremely low birth weight preterm infants.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Article
- Evaluation and validation of a prediction model for extubation success in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveStudies of extubation in preterm infants often define extubation success as a lack of reintubation within a specified time window. However, the duration of observation that defines extubation success in preterm infants has not been validated. The purpose of this study was to systematically review published definitions of extubation success in very preterm infants and to analyse the effect of the definition of extubation success on the reported rates of reintubation.
designStudies including very preterm infants published between 1 January 2002 and 30 June 2012 that reported reintubation as an outcome were reviewed for definitions of extubation success. Stepwise multivariable linear regression was used to explore variables associated with rate of reintubation.
resultsTwo independent reviewers performed the search with excellent agreement (κ=0.93). Of the 44 eligible studies, 31 defined a window of observation that ranged from 12 to 168 h (7 days). Extubation and reintubation criteria were highly variable. The mean±SD reintubation rate across all studies was 25±9%. In studies of infants with median birth weight (BW) ≤1000 g, reintubation rates steadily increased as the window of observation increased, without apparent plateau (p = 0.001). This trend was not observed in studies of larger infants (p = 0.85).
conclusionsVariability in the reported definitions of extubation success makes it difficult to compare extubation strategies across studies. The appropriate window of observation following extubation may depend on the population. In infants with BW ≤1000 g, even a week of observation may fail to identify some who will require reintubation.
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