ArticleVeterinary research communications2014
Protective effect of oral administration of transgenic tobacco seeds against verocytotoxic Escherichia coli strain in piglets.
Article in Veterinary research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medicinal plants--prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review.BMC veterinary research · 2016Pooled it
- Tannic acid-mediated gut microbes for enhanced intestinal immunity in Escherichia coli-challenged weaned piglets.Journal of animal science · 2026Article
- LiveFrontiers in veterinary science · 2026Article
- Impact of low-crude protein and insoluble fiber diets on post-weaning diarrhea, growth performance, intestinal morphology, and gene expression for nursery pigs with natural rotavirus and subject to enterotoxigenicTranslational animal science · 2026Article
- Evaluation of Phaseolus vulgaris lec- lpa as Alternative Protein Source on Growth Performances, Health Status, Faecal Minerals and Gut Microbiota in Weaned Piglet's Diet.Veterinary medicine and science · 2025Article
- Evaluation of F18 enterotoxigenicFrontiers in veterinary science · 2025Article
- Assessment of the antibacterial and antioxidant activities of seaweed-derived extracts.Scientific reports · 2024Article
- Seed-specific expression of porcine verotoxigenic Escherichia coli antigens in tobacco plants as a potential model of edible vaccines.Veterinary research communications · 2024Article
- Chemical-functional characterization ofFrontiers in veterinary science · 2024Article
- The Effects of Milk Replacer Supplemented withVeterinary sciences · 2023Article
- Tobacco Seed-Based Oral Vaccination against Verocytotoxic O138Antibiotics (Basel, Switzerland) · 2023Article
- C500 variants conveying complete mucosal immunity against fatal infections of pigs withFrontiers in microbiology · 2023Article
- Protective effect of phytogenic plus short and medium-chain fatty acids-based additives in enterotoxigenic Escherichia coli challenged piglets.Veterinary research communications · 2023Article
- Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis.Frontiers in plant science · 2022Article
- Investigation of the growth performance, blood status, gut microbiome and metabolites of rabbit fed with low-nicotine tobacco.Frontiers in microbiology · 2022Article
- Translational Approach to Induce and Evaluate VerocytotoxicAnimals : an open access journal from MDPI · 2021Article
- Evaluation of Adhesive Characteristics ofMicroorganisms · 2021Article
- Mint Oils: In Vitro Ability to Perform Anti-Inflammatory, Antioxidant, and Antimicrobial Activities and to Enhance Intestinal Barrier Integrity.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Evaluation of Tannin Extracts, Leonardite and Tributyrin Supplementation on Diarrhoea Incidence and Gut Microbiota of Weaned Piglets.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of transgenic plants as delivery system for antigenic proteins is attractive for its simplicity and increases likelihood for local immune response at sites of infection. The aim of this study was to evaluate the protective effect of oral administration of tobacco seeds, expressing the FedA, the major protein of the F18 adhesive fimbriae, and B subunit of verocytotoxin, against verocytotoxin-producing E. coli (VTEC) strain in piglets. Forty-three early weaned piglets, were randomly divided into 4 experimental groups: 3 test groups and a control. Treatment groups orally received a bolus, with different dose of tobacco seeds on 0, 1, 2, 14 days post primary administration. After challenge, with 1*10(10) CFU of O138 Escherichia coli strain, piglets showed clinical scores significantly higher in the control group compared to orally immunized groups (P < 0.05) and the latter showed a faster recovery than in CG. In conclusion, oral administration of recombinant tobacco seeds expressing antigenic proteins against VTEC strains can induce a protective effect against challenger strain in piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.