Evidence map›Paper›PMID 24249316›Full record

ArticleWiener klinische Wochenschrift2014

Bilateral pulmonary embolism in twins with PAI-1 4G/5G gene polymorphism: a case report.

Andreas Kronbichler, Peter Oelzner, Günter Syrbe, Eric Lopatta, Gunter Wolf, Thomas Neumann

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Wiener klinische Wochenschrift, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andreas KronbichlerDepartment of Internal Medicine III, Jena University-Hospital, Erlanger Allee 101, 07747, Jena, Germany.
Peter Oelzner
Günter Syrbe
Eric Lopatta
Gunter Wolf
Thomas Neumann
Jena University Hospital · DEAsklepios Fachklinikum Brandenburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aetiology of venous thromboembolism in adolescents is frequently associated with hereditary abnormalities of the coagulation system, autoimmune disorders or malignancies. The advent of specific laboratory tests has refined the identification of genetic traits. In this case report, we describe the occurrence of pulmonary embolism in young twins. Intensive tumour screening remained unremarkable. Evaluation of established risk factors for a clotting disorder remained negative, with the exception of a plasminogen activator inhibitor-1 4G/5G polymorphism. Despite the mild association accompanied by the presence of the 4G allele, this polymorphism might predispose to venous thromboembolism in some cases in general and in our case in particular.

Indexed as

AdultFemaleGenetic Predisposition to DiseaseHumansMalePlasminogen Activator Inhibitor 1Polymorphism, Single NucleotidePulmonary EmbolismTwinsVenous ThrombosisPlasminogen Activator Inhibitor 1SERPINE1 protein, human

Identifiers

PMID24249316
OpenAlexW201862317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.