Evidence map›Paper›PMID 24249001›Full record

ArticleJournal of epidemiology and community health2014

Association of socioeconomic position with smoking and mortality: the contribution of early life circumstances in the 1946 birth cohort.

Ingrid Giesinger, Peter Goldblatt, Philippa Howden-Chapman, Michael Marmot, Diana Kuh, Eric Brunner

Abstract read
In one paragraph

Article in Journal of epidemiology and community health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Mental stress as a trigger of cardiovascular events: A narrative review.European journal of clinical investigation · 2026
    Review
  3. Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025
    Review
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  14. Retrospective Reports of Negative Early Life Events Over a 4-Year Period: A Test of Measurement Invariance and Response Consistency.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017
    Article
  15. Article
  16. Social factors and cardiovascular morbidity.Neuroscience and biobehavioral reviews · 2017
    Review
  17. Article
  18. Baby Boomers and Birth Certificates: Early-Life Socioeconomic Status and Cancer Risk in Adulthood.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ingrid GiesingerInstitute of Epidemiology and Health Care, University College London, , London, UK.
Peter Goldblatt
Philippa Howden-Chapman
Michael Marmot
Diana Kuh
Eric Brunner

Funding

British Heart Foundation RG/07/008/23674Medical Research Council G0100222Medical Research Council G0601647Medical Research Council G0701830Medical Research Council G0902037Medical Research Council G1000616Medical Research Council G19/35Medical Research Council G8802774Medical Research Council MC_UU_12019/01Medical Research Council MC_UU_12019/1Medical Research Council MR/K013351/1
6 · The paper itself

Abstract

backgroundA large part of the socioeconomic mortality gradient can be statistically accounted for by social patterning of adult health behaviours. However, this statistical explanation does not consider the early life origins of unhealthy behaviours and increased mortality risk.

methodsAnalysis is based on 2132 members of the MRC National Survey of Health and Development with mortality follow-up and complete data. Smoking behaviour was summarised by pack-years of exposure. Socioeconomic circumstances were measured in childhood (father's social class (age 4), maternal education (age 6)) and age 26 (education attainment, home ownership, head of household social class). We estimated the direct effect of early circumstances, the indirect effect through smoking and the independent direct effect of smoking on inequality in all-cause mortality from age 26 to 66.

resultsMortality risk was higher in those with lower socioeconomic position at age 26, with a sex-adjusted HR (relative index of inequality) of 1.97 (95% CI 1.18 to 3.28). Smoking and early life socioeconomic indicators together explained 74% of the socioeconomic gradient in mortality (the gradient). Early life circumstances explained 47% of the gradient, 23.5% directly and 23.0% indirectly through smoking. The explanatory power of smoking behaviour for the gradient was reduced from 50.8% to 28% when early life circumstances were added to the model.

conclusionsEarly life socioeconomic circumstances contributed importantly to social inequality in adult mortality. Our life-course model focusing on smoking provides evidence that social inequalities in health will persist unless prevention strategies tackle the intergenerational transmission of disadvantage and risk.

Indexed as

Health Status DisparitiesHealth Status IndicatorsLife Change EventsSocial ClassAdultAgedCohort StudiesEnglandFemaleFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedMortalityMothersCohort studiesInequalitiesMortalitySmokingSocio-Economic

Identifiers

PMID24249001
PMCPMC4157998

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.