ArticleNeurochemical research2014
Electrical stimulation induces calcium-dependent neurite outgrowth and immediate early genes expressions of dorsal root ganglion neurons.
Article in Neurochemical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects.Muscle & nerve · 2025Pooled it
- Neuropathic Corneal Pain and Blepharospasm: A Case Series.Diagnostics (Basel, Switzerland) · 2026Article
- Non-invasive electrical stimulation restores corneal nerve density and sensory function in diabetic neuropathy via KCNN-dependent mechanism.Communications biology · 2026Article
- Rochelle salt-based biodegradable piezoelectric devices for nerve regeneration and intestinal motility monitoring.Nature communications · 2026Article
- Exogenous electrical stimulation combined with electroactive nanopatches promotes cutaneous nerve regeneration and wound healing.Frontiers in bioengineering and biotechnology · 2026Article
- Electrotherapy in the management of neuropathic corneal pain: narrative review.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Non-invasive electrical stimulation restores corneal nerve density and function in diabetic neuropathy via KCNN-dependent mechanism.Research square · 2025Article
- Facial nerve pathology: emerging strategies for regeneration and functional restoration.Journal of materials chemistry. B · 2025Review
- Development and application of a novel multi-channel in vitro electrical stimulator for cellular research.BMC biomedical engineering · 2025Article
- Mapping the hotspots and future trends of electrical stimulation for peripheral nerve injury: A bibliometric analysis from 2002 to 2023.International wound journal · 2024Article
- In Vitro Imaging and Molecular Characterization of CaInternational journal of molecular sciences · 2023Article
- The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neuronsFrontiers in cellular neuroscience · 2023Article
- The Effect of Electrical Stimulation on Nerve Regeneration Following Peripheral Nerve Injury.Biomolecules · 2022Review
- Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation.Journal of cell science · 2022Article
- Ultrasound Stimulation Increases Neurite Regeneration in Injured Dorsal Root Ganglion Neurons through Mammalian Target of Rapamycin Activation.Brain sciences · 2020Article
- Graphene-Based Nanocomposites for Neural Tissue Engineering.Molecules (Basel, Switzerland) · 2019Review
- Validation of electrical stimulation models: intracellular calcium measurement in three-dimensional scaffolds.Journal of neurophysiology · 2017Article
- Potential Mechanism of Neurite Outgrowth Enhanced by Electrical Stimulation: Involvement of MicroRNA-363-5p Targeting DCLK1 Expression in Rat.Neurochemical research · 2017Article
- Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway.Lasers in medical science · 2017Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate cultured dorsal root ganglion neurons (DRGNs) and we've found that ES could greatly promote neurite outgrowth, and calcium signaling was involved in the ES-induced neurite extension in our research. Detailed pharmacological tests indicated that ES-induced elevation of intracellular free calcium concentration ([Ca(2+)] i ) in DRGNs was realized predominately via calcium influx and calcium mobilization, both of which contributed to enhancing neurite outgrowth promoted by ES. Additionally, a calcium-triggered c-fos and brain-derived neurotrophic factor (BDNF) transcription and/or translation were discovered during the ES-induced neurite outgrowth of cultured DRGNs. To our knowledge, this is the first case of detailed snapshots of studying calcium-dependent neurite outgrowth and BDNF and c-fos expressions in DRGNs induced by ES, which may provide experimental evidence for applying ES to promote regeneration of injured nerves and to enhance synthesis of c-fos and BDNF in neurons, and may also help explore the complex molecular cascades underlying the progressive pathophysiological changes in the ES-induced nerve regeneration in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.