ArticleProceedings of the National Academy of Sciences of the United States of America2013
Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed, 115 citations in OpenAlex.
- Integrating mosquito genomics into simulation modeling: opportunities for better-informed biocontrol.Current opinion in insect science · 2026Review
- Ecological analysis of mosquito larval communities in Burkina Faso to inform environmental monitoring of genetic control programs.Scientific reports · 2026Article
- Defining the genetics of the widely used G3 strain of the mosquito, Anopheles gambiae.Scientific reports · 2025Article
- Insecticide resistance mutations of Anopheles species in the Republic of Korea.PLoS neglected tropical diseases · 2025Article
- Unravelling the role of mitochondrial DNA in hybrid incompatibility within species of the Anopheles gambiae complex.Scientific reports · 2024Article
- Population genomic evidence of a putative 'far-west' African cryptic taxon in the Anopheles gambiae complex.Communications biology · 2024Article
- Mitochondrial Variation in Anopheles gambiae and Anopheles coluzzii: Phylogeographic Legacy and Mitonuclear Associations With Metabolic Resistance to Pathogens and Insecticides.Genome biology and evolution · 2024Article
- Considerations for first field trials of low-threshold gene drive for malaria vector control.Malaria journal · 2024Review
- Speciation within theResearch square · 2024Article
- Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea.Scientific reports · 2023Article
- Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii.Insect molecular biology · 2023Article
- Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops.Frontiers in bioengineering and biotechnology · 2023Article
- The diverse effects of phenotypic dominance on hybrid fitness.Evolution; international journal of organic evolution · 2022Article
- High Levels of Admixture inInsects · 2022Article
- A need for standardized reporting of introgression: Insights from studies across eukaryotes.Evolution letters · 2022Article
- Perfect association between spatial swarm segregation and the X-chromosome speciation island in hybridizing Anopheles coluzzii and Anopheles gambiae populations.Scientific reports · 2022Article
- Spatial modelling for population replacement of mosquito vectors at continental scale.PLoS computational biology · 2022Article
- Selection of sites for field trials of genetically engineered mosquitoes with gene drive.Evolutionary applications · 2021Article
- Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae.Molecular ecology resources · 2021Article
- Unravelling population structure heterogeneity within the genome of the malaria vector Anopheles gambiae.BMC genomics · 2021Article
10 more citing papers are in PubMed but not listed here.
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8 authors at 4 institutions in 3 countries.
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Abstract
The M and S forms of Anopheles gambiae have been the focus of intense study by malaria researchers and evolutionary biologists interested in ecological speciation. Divergence occurs at three discrete islands in genomes that are otherwise nearly identical. An "islands of speciation" model proposes that diverged regions contain genes that are maintained by selection in the face of gene flow. An alternative "incidental island" model maintains that gene flow between M and S is effectively zero and that divergence islands are unrelated to speciation. A "divergence island SNP" assay was used to explore the spatial and temporal distributions of hybrid genotypes. Results revealed that hybrid individuals occur at frequencies ranging between 5% and 97% in every population examined. A temporal analysis revealed that assortative mating is unstable and periodically breaks down, resulting in extensive hybridization. Results suggest that hybrids suffer a fitness disadvantage, but at least some hybrid genotypes are viable. Stable introgression of the 2L speciation island occurred at one site following a hybridization event.
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