ArticleProceedings of the National Academy of Sciences of the United States of America2013
Estimating functional connectivity in an electrically coupled interneuron network.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Prevalence and practices of immunofluorescent cell image processing: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Strategies to Decipher Neuron Identity from Extracellular Recordings in Behaving Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Extensive GJD2 Expression in the Song Motor Pathway Reveals the Extent of Electrical Synapses in the Songbird Brain.Biology · 2021Article
- Article
- Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.Scientific reports · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though it has been known for some time that in many mammalian brain areas interneurons are electrically coupled, a quantitative description of the network electrical connectivity and its impact on cellular passive properties is still lacking. Approaches used so far to solve this problem are limited because they do not readily distinguish junctions among direct neighbors from indirect junctions involving intermediary, multiply connected cells. In the cerebellar cortex, anatomical and functional evidence indicates electrical coupling between molecular layer interneurons (basket and stellate cells). An analysis of the capacitive currents obtained under voltage clamp in molecular layer interneurons of juvenile rats or mice reveals an exponential component with a time constant of ~20 ms, which represents capacitive loading of neighboring cells through gap junctions. These results, taken together with dual cell recording of electrical synapses, have led us to estimate the number of direct neighbors to be ~4 for rat basket cells and ~1 for rat stellate cells. The weighted number of neighbors (number of neighbors, both direct and indirect, weighted with the percentage of voltage deflection at steady state) was 1.69 in basket cells and 0.23 in stellate cells. The last numbers indicate the spread of potential changes in the network and serve to estimate the contribution of gap junctions to cellular input conductance. In conclusion the present work offers effective tools to analyze the connectivity of electrically connected interneuron networks, and it indicates that in juvenile rodents, electrical communication is stronger among basket cells than among stellate cells.
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