ArticleMolecular systems biology2013
Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Metabolic changes inmBio · 2024Article
- ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii.PLoS computational biology · 2024Article
- Architect: A tool for aiding the reconstruction of high-quality metabolic models through improved enzyme annotation.PLoS computational biology · 2022Article
- Toxoplasma infection in male mice alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease.PLoS neglected tropical diseases · 2022Article
- Article
- Amino Acid Metabolism in Apicomplexan Parasites.Metabolites · 2021Review
- Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection byPathogens (Basel, Switzerland) · 2020Article
- Article
- Comparative genomic analysis of three intestinal species reveals reductions in secreted pathogenesis determinants in bovine-specific and non-pathogenicMicrobial genomics · 2020Article
- Vitamin and cofactor acquisition in apicomplexans: SynthesisThe Journal of biological chemistry · 2020Review
- Biomedical applications of genome-scale metabolic network reconstructions of human pathogens.Current opinion in biotechnology · 2018Review
- A Genome-Scale Metabolic Reconstruction ofFrontiers in genetics · 2018Article
- Metabolic interactions betweenF1000Research · 2018Review
- Lessons from the genomes and transcriptomes of filarial nematodes.Molecular and biochemical parasitology · 2017Review
- Genomics of apicomplexan parasites.Critical reviews in biochemistry and molecular biology · 2017Review
- Toxoplasma growth in vitro is dependent on exogenous tyrosine and is independent of AAH2 even in tyrosine-limiting conditions.Experimental parasitology · 2017Article
- The genome of Onchocerca volvulus, agent of river blindness.Nature microbiology · 2016Article
- Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection.Journal of neuroimmunology · 2016Article
- Determination of Ancylostoma caninum ova viability using metabolic profiling.Parasitology research · 2016Article
- Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.Nature communications · 2016Article
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Authors and funding
7 authors.
Funding
Abstract
Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain-specific infectivity differences, we present a constraint-based metabolic model of the opportunistic parasite, Toxoplasma gondii. Dominated by three clonal strains (Type I, II, and III demonstrating distinct virulence profiles), T. gondii exhibits a remarkably broad host range. Integrating functional genomic data, our model (which we term as iCS382) reveals that observed strain-specific differences in growth rates are driven by altered capacities for energy production. We further predict strain-specific differences in drug susceptibilities and validate one of these predictions in a drug-based assay, with a Type I strain demonstrating resistance to inhibitors that are effective against a Type II strain. We propose that these observed differences reflect an evolutionary strategy that allows the parasite to extend its host range, as well as result in a subsequent partitioning into discrete strains that display altered virulence profiles across different hosts, different organs, and even cell types.
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