Evidence map›Paper›PMID 24247655›Full record

ReviewLeukemia2014

Inherited genetic susceptibility to multiple myeloma.

G J Morgan, D C Johnson, N Weinhold, H Goldschmidt, O Landgren, H T Lynch, K Hemminki, R S Houlston

Abstract readReview
PubMed Publisher
In one paragraph

Review in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  16. Review
  17. Second malignancies in multiple myeloma; emerging patterns and future directions.Best practice & research. Clinical haematology · 2020
    Review
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

G J MorganHaemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
D C JohnsonHaemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.ORCID 0000000308873343
N WeinholdDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
H GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
O LandgrenMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
H T LynchDepartment of Preventive Medicine, Creighton's Hereditary Cancer Center, Omaha, NE, USA.
K Hemminki1] Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany [2] Center for Primary Health Care Research, Lund University, Malmö, Sweden.
R S HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
Institute of Cancer Research · GBHeidelberg University · DECreighton University · USGerman Cancer Research Center · DENational Institutes of Health · US

Funding

Cancer Research UK 15116
6 · The paper itself

Abstract

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

Indexed as

Genetic Predisposition to DiseaseFemaleHumansMaleMultiple MyelomaPedigree

Identifiers

PMID24247655
OpenAlexW2018191098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.