Evidence map›Paper›PMID 24247473›Full record

ArticleCritical care medicine2014

Physical complications in acute lung injury survivors: a two-year longitudinal prospective study.

Eddy Fan, David W Dowdy, Elizabeth Colantuoni, Pedro A Mendez-Tellez, Jonathan E Sevransky, Carl Shanholtz, Cheryl R Dennison Himmelfarb, Sanjay V Desai, Nancy Ciesla, Margaret S Herridge and 2 more

10 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 291 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 10 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02864745 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Functional Electrical Stimulation-assisted Cycle Ergometry in Critically Ill: Linking Deranged Muscle Physiology to Long-term Functional Outcome

TypeinterventionalSponsorCharles University, Czech RepublicRan2016 to 2020Enrolled150ConditionsCritical IllnessArmsfunctional electrical stimulation-assisted cycle ergometry, standard rehabilitation
NCT03160547 nacompletednot on this mapstarted 2017, after this paper: background citation

The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial

TypeinterventionalSponsorClinical Evaluation Research Unit at Kingston General HospitalRan2017 to 2021Enrolled1,329ConditionsCritical Illness, MalnutritionArmsUsual Protein/Amino Acid Group, Higher Protein/Amino Acid Group
NCT03469882 nacompletednot on this mapstarted 2018, after this paper: background citation

High Protein Intake and Early Exercise in Adult Intensive Care Patients: Impact on Functional Outcomes. A Randomized Controlled Phase II Trial.

TypeinterventionalSponsorHospital Sao DomingosRan2018 to 2020Enrolled180ConditionsCritically Ill PatientsArmsHigh protein nutrition, Cycle ergometry exercise, Usual care group
NCT03717831 completednot on this mapstarted 2018, after this paper: background citation

Muscle Dysfunction and Functional Outcomes in Patients With and Surviving Critical Illness

TypeobservationalSponsorUniversity of KentuckyRan2018 to 2019Enrolled66ConditionsCritical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle WeaknessArmsObservational study of standard of care
NCT04242966 phase3withdrawnnot on this mapstarted 2020, after this paper: background citation

The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial: The EFFORT Ultrasound a Sub-study

TypeinterventionalSponsorClinical Evaluation Research Unit at Kingston General HospitalRan2020 to 2022Enrolled0ConditionsCritical Illness, MalnutritionArmsUsual Care, Higher Protein/Amino Acid Group, Ultrasound measure
NCT04640441 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Sit-to-Stand Intervention in the Intensive Care Unit Survivors: A Randomized Controlled Trial

TypeinterventionalSponsorNational Taiwan University HospitalRan2020 to 2024Enrolled246ConditionsUnable to Sit-to-stand, ICU SurvivorArmsSit-to-stand Intervention
NCT05149430 completednot on this mapstarted 2019, after this paper: background citation

Evolution and Follow-up of the Quality of Life and Functional Capacity, in Patients Admitted in Ward Room, Post-hospitality in the Intensive Care Unit. Descriptive Study

TypeobservationalSponsorSanatorio Anchorena San MartinRan2019 to 2020Enrolled101ConditionsPost-intensive Care SyndromeArmsObservational Quality of life and functional capacity
NCT06012201 unknown statusnot on this mapstarted 2023, after this paper: background citation

Relationship Between Protein Intake and ICU Skeletal Muscle Weakness

Typeobservational_patient_registrySponsorTufts Medical CenterRan2023 to 2023Enrolled60ConditionsAtrophy of Rectus Femoris Muscle (Physical Finding)
NCT07093125 recruitingnot on this mapstarted 2025, after this paper: background citation

An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)

Typeobservational_patient_registrySponsorUniversita degli Studi di GenovaRan2025 to 2029Enrolled2,400ConditionsMechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
NCT07188350 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuromuscular Electrical Stimulation of Lower Limbs in Patients Undergoing Invasive Mechanical Ventilation: Randomized Clinical Trial

TypeinterventionalSponsorHospital Moinhos de VentoRan2025 to 2027Enrolled150ConditionsMechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness ConditionArmsConventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
3 · Its place in the literature

Who cites it

291 citing papers in PubMed, 10 syntheses or guidelines pooled it, 595 citations in OpenAlex.

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  12. Perceived barriers to early goal-directed mobility in the intensive care unit: Results of a quality improvement evaluation.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2022
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  16. Patients' Adaptations After Acute Respiratory Distress Syndrome: A Qualitative Study.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2021
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231 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Eddy Fan1Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. 2Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD. 3Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 4Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 5Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. 6Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA. 7Division of Pulmonary and Critical Care Medicine, University of Maryland, Baltimore, MD. 8Johns Hopkins University School of Nursing, Baltimore, MD. 9Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. 10Department of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD. 11Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
David W Dowdy
Elizabeth Colantuoni
Pedro A Mendez-Tellez
Jonathan E Sevransky
Carl Shanholtz
Cheryl R Dennison Himmelfarb
Sanjay V Desai
Nancy Ciesla
Margaret S Herridge
Peter J Pronovost
Dale M Needham
University of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GARCIA, JOE G. N. · 2003 to 2007
$21.3M
Five Year Outcomes from Acute Lung InjuryK24HL088551 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PRONOVOST, PETER J. · 2009 to 2013
$975k
CIHRNCATS NIH HHS UL1 TR001079NHLBI NIH HHS K24 HL088551NHLBI NIH HHS #P050 HL73994NHLBI NIH HHS P50 HL073994
6 · The paper itself

Abstract

objectiveSurvivors of severe critical illness frequently develop substantial and persistent physical complications, including muscle weakness, impaired physical function, and decreased health-related quality of life. Our objective was to determine the longitudinal epidemiology of muscle weakness, physical function, and health-related quality of life and their associations with critical illness and ICU exposures.

designA multisite prospective study with longitudinal follow-up at 3, 6, 12, and 24 months after acute lung injury.

settingThirteen ICUs from four academic teaching hospitals. PATIENTS: Two hundred twenty-two survivors of acute lung injury.

interventionsNone. MEASUREMENTS AND MAIN

resultsAt each time point, patients underwent standardized clinical evaluations of extremity, hand grip, and respiratory muscle strength; anthropometrics (height, weight, mid-arm circumference, and triceps skin fold thickness); 6-minute walk distance, and the Medical Outcomes Short-Form 36 health-related quality of life survey. During their hospitalization, survivors also had detailed daily evaluation of critical illness and related treatment variables. Over one third of survivors had objective evidence of muscle weakness at hospital discharge, with most improving within 12 months. This weakness was associated with substantial impairments in physical function and health-related quality of life that persisted at 24 months. The duration of bed rest during critical illness was consistently associated with weakness throughout 24-month follow-up. The cumulative dose of systematic corticosteroids and use of neuromuscular blockers in the ICU were not associated with weakness.

conclusionsMuscle weakness is common after acute lung injury, usually recovering within 12 months. This weakness is associated with substantial impairments in physical function and health-related quality of life that continue beyond 24 months. These results provide valuable prognostic information regarding physical recovery after acute lung injury. Evidence-based methods to reduce the duration of bed rest during critical illness may be important for improving these long-term impairments.

Indexed as

Critical IllnessHealth StatusQuality of LifeAcademic Medical CentersAcute Lung InjuryAdultAgedBody Weights and MeasuresExercise TestFemaleHand StrengthHumansIntensive Care UnitsLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID24247473
PMCPMC3959239
OpenAlexW2331048724

What OpenQuestion holds

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Registered trials

and 4 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.