ArticleAntimicrobial agents and chemotherapy2014
Susceptibility profiles of Nocardia isolates based on current taxonomy.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- The species distribution and antimicrobial resistance profiles of Nocardia species in China: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2023Pooled it
- Clinical Characteristics and Treatment Outcome of Central Nervous System Nocardiosis: A Systematic Review of Reported Cases.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Pooled it
- Nocardiosis-an uncommon infection in patients with myasthenia gravis: report of three cases and review of literature.BMJ case reports · 2020Pooled it
- Nocardiosis Associated with Primary Immunodeficiencies (Nocar-DIP): an International Retrospective Study and Literature Review.Journal of clinical immunology · 2020Pooled it
- Risk factors for mortality after nocardiosis in Southern France (2014-2024).IJID regions · 2026Article
- Pulmonary Nocardia otitidiscaviarum in immunocompetent individuals: a case series and literature review.BMC infectious diseases · 2026Review
- Epidemiology, clinical treatment and outcomes, susceptibility patterns and genotypic analysis of 214Frontiers in cellular and infection microbiology · 2026Article
- Risk Factors and Outcomes of Disseminated Nocardiosis Across Host Risk Groups.Open forum infectious diseases · 2026Article
- Pulmonary Nocardiosis Diagnosed by Plasma Metagenomic Next-Generation Sequencing in a Patient With Recurrent Febrile Neutropenia.Case reports in infectious diseases · 2026Article
- Research progress on clinical challenges and prevention strategies of drug-resistantFrontiers in public health · 2026Review
- The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection.Scientific reports · 2025Article
- Nocardia Nova bacteremia and viral pneumonia in a breast cancer patient post modified radical mastectomy: a case report.BMC infectious diseases · 2025Article
- Disseminated Nocardia species infection manifested with multiple brain abscesses and lung involvement in an immunocompetent patient: a case report.Journal of medical case reports · 2025Article
- A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient.BMC infectious diseases · 2025Article
- Pulmonary Nocardiosis Due to Nocardia exalbida Infection Following Living-donor Liver Transplantation.Internal medicine (Tokyo, Japan) · 2025Review
- Pulmonary nocardiosis in kidney transplant recipients: A case report and analysis of 60 published cases.IDCases · 2025Article
- Genomic and phenotypic characterization of antimicrobial resistance in clinicalFrontiers in cellular and infection microbiology · 2025Article
- Epidemiology and Drug Resistance of Pulmonary Nocardiosis Among Tuberculosis-Suspected Patients in Guangzhou, China.Infection and drug resistance · 2025Article
- Article
- Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection in children with Neuromyelitis Optica Spectrum Disorders: a case report and literature review.Italian journal of pediatrics · 2024Review
24 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Nocardia has undergone rapid taxonomic expansion in recent years, and an increasing number of species are recognized as human pathogens. Many established species have predictable antimicrobial susceptibility profiles, but sufficient information is often not available for recently described organisms. Additionally, the effectiveness of sulfonamides as first-line drugs for Nocardia has recently been questioned. This led us to review antimicrobial susceptibility patterns for a large number of molecularly identified clinical isolates. Susceptibility results were available for 1,299 isolates representing 39 different species or complexes, including 11 that were newly described, during a 6-year study period. All tested isolates were susceptible to linezolid. Resistance to trimethoprim-sulfamethoxazole (TMP-SMX) was rare (2%) except among Nocardia pseudobrasiliensis (31%) strains and strains of the N. transvalensis complex (19%). Imipenem susceptibility varied for N. cyriacigeorgica and N. farcinica, as did ceftriaxone susceptibility of the N. nova complex. Resistance to more than one of the most commonly used drugs (amikacin, ceftriaxone, TMP-SMX, and imipenem) was highest for N. pseudobrasiliensis (100%), N. transvalensis complex (83%), N. farcinica (68%), N. puris (57%), N. brasiliensis (51%), N. aobensis (50%), and N. amikacinitolerans (43%). Thus, while antimicrobial resistance can often be predicted, susceptibility testing should still be considered when combination therapy is warranted, for less well characterized species or those with variable susceptibility profiles, and for patients with TMP-SMX intolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.