Evidence map›Paper›PMID 24247114›Full record

ReviewCurrent opinion in rheumatology2014

Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity.

Samuel B Brusca, Steven B Abramson, Jose U Scher

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 132 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 5 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01198509 nacompletednot on this map

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

TypeinterventionalSponsorNYU Langone HealthRan2010 to 2013Enrolled178ConditionsRheumatoid Arthritis, Psoriatic Arthritis, Periodontal DiseaseArmsdoxycycline, vancomycin
NCT03058900 nacompletednot on this mapstarted 2017, after this paper: background citation

Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Peripheral Psoriatic Arthritis: a 6-month, Double-Blind, Randomized, Placebo-Controlled Trial

TypeinterventionalSponsorOdense University HospitalRan2017 to 2020Enrolled31ConditionsPsoriatic ArthritisArmsFecal microbiota transplantation (FMT), Drug: Placebo (saline), Methotrexate (MTX)
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 5 syntheses or guidelines pooled it, 228 citations in OpenAlex.

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  17. Frontiers in immunology · 2025
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Samuel B BruscaaNew York University School of Medicine bDivision of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Steven B Abramson
Jose U Scher
New York University · USCenter for Rheumatology · US

Funding

The Role of Gut and Skin Microbiome in Psoriatic ArthritisK23AR064318 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHER, JOSE U. · 2013 to 2016
$589k
NIAMS NIH HHS K23 AR064318
6 · The paper itself

Abstract

purpose of reviewDespite the progress toward understanding the molecular pathogenesis of rheumatoid arthritis (RA), its cause remains elusive. Genes are important but rather insufficient to explain the majority of RA cases. This review describes the novel data supporting the microbiome and its interactions with the human host as potential en('in')vironmental factors in RA pathogenesis. RECENT

findingsAnimal models of inflammatory arthritis have shown that the presence of bacteria in mucosal surfaces is sufficient to alter local and systemic host immune responses and elicit joint inflammation. Human RA studies have focused on three mucosal sites: the gut, the gingiva, and the respiratory tree. The oral microbiome, and specifically Porphyromonas gingivalis, has long been implicated. Novel sequencing technologies have allowed investigations into the role of the gut microbiome in the development of autoimmune arthritis. Most recently, the pulmonary parenchyma has also been described as yet another possible mucosal site of initiation of autoimmunity in RA. SUMMARY: Emerging data implicate the microbiome in RA pathogenesis. Mucosal sites exposed to a high load of bacterial antigens--such as the periodontium, lung, and gut--may represent the initial site of autoimmune generation. If validated, these findings could lead to the discovery of potential biomarkers and therapeutic approaches in the preclinical and clinical phases of RA.

Indexed as

MicrobiotaAnimalsAntigens, BacterialArthritis, ExperimentalArthritis, RheumatoidAutoimmunityDisease Models, AnimalDysbiosisHumansInflammationMiceMucous MembranePeriodontal DiseasesAntigens, Bacterial

Identifiers

PMID24247114
PMCPMC4011633
OpenAlexW2131058075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.