ArticleScientific reports2013
Inflammation and immune system activation in aging: a mathematical approach.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder.Frontiers in molecular neuroscience · 2026Review
- Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation.Molecular medicine reports · 2022Article
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- Review
- Whole Exome and Transcriptome RNA-Sequencing Model for the Diagnosis of Prostate Cancer.ACS omega · 2020Article
- Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children.Brain, behavior, & immunity - health · 2020Article
- Article
- Transcriptomic changes in the prefrontal cortex of rats as a function of age and cognitive engagement.Neurobiology of learning and memory · 2019Article
- Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development.PloS one · 2017Article
- FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells.The Journal of biological chemistry · 2016Article
- Independent validation of a mathematical genomic model for survival of glioma patients.American journal of cancer research · 2016Article
- Adversity in preschool-aged children: Effects on salivary interleukin-1β.Development and psychopathology · 2015Article
- Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.Scientific reports · 2015Article
- A common variant in MTHFR influences response to chemoradiotherapy and recurrence of rectal cancer.American journal of cancer research · 2015Article
- Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone.Frontiers in neurology · 2015Article
- A mathematical model for short-term vs. long-term survival in patients with glioma.American journal of cancer research · 2014Article
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1 author.
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Abstract
Memory and learning declines are consequences of normal aging. Since those functions are associated with the hippocampus, I analyzed the global gene expression data from post-mortem hippocampal tissue of 25 old (age ≥ 60 yrs) and 15 young (age ≤ 45 yrs) cognitively intact human subjects. By employing a rigorous, multi-method bioinformatic approach, I identified 36 genes that were the most significant in terms of differential expression; and by employing mathematical modeling, I demonstrated that 7 of the 36 genes were able to discriminate between the old and young subjects with high accuracy. Remarkably, 90% of the known genes from those 36 most significant genes are associated with either inflammation or immune system activation. This suggests that chronic inflammation and immune system over-activity may underlie the aging process of the human brain, and that potential anti-inflammatory treatments targeting those genes may slow down this process and alleviate its symptoms.
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