ArticleDevelopmental biology2014
Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells.Nature genetics · 2020Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.Nucleic acids research · 2018Article
- Article
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development.Developmental biology · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.Developmental biology · 2017Article
- Shared and distinct mechanisms of atonal regulation in Drosophila ocelli and compound eyes.Developmental biology · 2016Article
- Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- ato-Gal4 fly lines for gene function analysis: Eya is required in late progenitors for eye morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Article
- Eye selector logic for a coordinated cell cycle exit.PLoS genetics · 2015Article
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Authors and funding
7 authors.
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Abstract
Proneural transcription factors drive the generation of specialized neurons during nervous system development, and their dynamic expression pattern is critical to their function. The activation of the proneural gene atonal (ato) in the Drosophila eye disc epithelium represents a critical step in the transition from retinal progenitor cell to developing photoreceptor neuron. We show here that the onset of ato transcription depends on two distant enhancers that function differently in subsets of retinal progenitor cells. A detailed analysis of the crosstalk between these enhancers identifies a critical role for three binding sites for the Retinal Determination factors Eyeless (Ey) and Sine oculis (So). We show how these sites interact to induce ato expression in distinct regions of the eye field and confirm them to be occupied by endogenous Ey and So proteins in vivo. Our study suggests that Ey and So operate differently through the same 3' cis-regulatory sites in distinct populations of retinal progenitors.
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