ReviewBlood2014
Plasmodium falciparum picks (on) EPCR.
Review in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria.Infection · 2023Article
- Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated Hypercytokinemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Antithrombin protects against Plasmodium falciparum histidine-rich protein II-mediated inflammation and coagulation.Blood advances · 2022Article
- Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria.Blood advances · 2020Article
- Plasmodium falciparum histidine rich protein HRPII inhibits the anti-inflammatory function of antithrombin.Journal of thrombosis and haemostasis : JTH · 2020Article
- Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.Immunological reviews · 2020Review
- Activated protein C in neuroprotection and malaria.Current opinion in hematology · 2019Review
- Malaria infection promotes a selective expression of kinin receptors in murine liver.Malaria journal · 2019Article
- Tissue tropism in parasitic diseases.Open biology · 2019Review
- Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome.Journal of immunology research · 2019Article
- Severe malaria: what's new on the pathogenesis front?International journal for parasitology · 2017Review
- Article
- Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage.Frontiers in immunology · 2017Review
- The role of EPCR in the pathogenesis of severe malaria.Thrombosis research · 2016Review
- Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections.mBio · 2016Review
- Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS.Mediators of inflammation · 2016Article
- Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding.Journal of thrombosis and haemostasis : JTH · 2015Article
- Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.The American journal of tropical medicine and hygiene · 2015Review
- Review
- Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.Malaria journal · 2014Article
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
Abstract
Of all the outcomes of Plasmodium falciparum infection, the coma of cerebral malaria (CM) is particularly deadly. Malariologists have long wondered how some patients develop this organ-specific syndrome. Data from two recent publications support a novel mechanism of CM pathogenesis in which infected erythrocytes (IEs) express specific virulence proteins that mediate IE binding to the endothelial protein C receptor (EPCR). Malaria-associated depletion of EPCR, with subsequent impairment of the protein C system promotes a proinflammatory, procoagulant state in brain microvessels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.