Trial reportJournal of neonatal-perinatal medicine2013
Does daily kangaroo care provide sustained pain and stress relief in preterm infants?
Trial report in Journal of neonatal-perinatal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Efficacy and safety of non-pharmacological interventions for endotracheal suctioning pain in preterm infants: A systematic review.Nursing open · 2023Pooled it
- Kangaroo Care for Relieving Neonatal Pain Caused by Invasive Procedures: A Systematic Review and Meta-Analysis.Computational intelligence and neuroscience · 2022Pooled it
- Pain and distress outcomes in infants and children: a systematic review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Pooled it
- Skin-to-skin care for procedural pain in neonates.The Cochrane database of systematic reviews · 2017Pooled it
- Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis.Pediatrics · 2016Pooled it
- First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit.Revista Brasileira de terapia intensivaPooled it
- Blinded randomized crossover trial: Skin-to-skin care vs. sucrose for preterm neonatal pain.Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Longer duration of kangaroo care improves neurobehavioral performance and feeding in preterm infants: a randomized controlled trial.Pediatric research · 2020Trial
- Sucrose vs. skin to skin care for preterm neonatal pain control-a randomized control trial.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Effect of zero-separation in mother-newborn care unit on preterm infant's stress and growth.The Indian journal of medical research · 2026Article
- Article
- Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials.BMC pediatrics · 2024Article
- Measuring experience of and satisfaction with newborn care: a scoping review of tools and measures.BMJ global health · 2023Article
- Kangaroo mother care (KMC) for procedural pain in infants: A meta-analysis from the current evidence of randomized control trials and cross-over trials.Journal of family medicine and primary care · 2022Review
- Co-bedding of Preterm Newborn Pigs Reduces Necrotizing Enterocolitis Incidence Independent of Vital Functions and Cortisol Levels.Frontiers in pediatrics · 2021Article
- State of the Art in Parent-Delivered Pain-Relieving Interventions in Neonatal Care: A Scoping Review.Frontiers in pediatrics · 2021Article
- Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability.Frontiers in psychiatry · 2020Review
- Managing Procedural Pain in the Neonate Using an Opioid-sparing Approach.Clinical therapeutics · 2019Review
- Pain management in newborns.Clinics in perinatology · 2014Review
- Reducing toxic stress in the neonatal intensive care unit to improve infant outcomes.Nursing outlookArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectives1. Determine whether stress in preterm infants, measured with salivary cortisol, decreases after five days of Kangaroo Care (KC) compared to five days of Standard Care (SC). 2. To determine whether kangaroo care provides sustainable pain relief beyond the period of skin-to-skin holding. STUDY
designPreterm infants (n = 38) born at 27-30 weeks gestational age were randomized to either the KC or the SC group and received the allocated intervention starting on day of life (DOL) five and continuing for five days. Salivary cortisol was collected on DOL five and again on DOL ten. Differences were analyzed using repeated measures ANOVA and t tests. Pain during nasal suctioning over five days was assessed using the Premature Infant Pain Profile (PIPP).
result1. Adequate saliva samples for salivary cortisol were collected for 13 KC infants and 11 SC infants. There was no main effect of group (p = 0.49), but there was a significant main effect of age (DOL five versus DOL ten), with salivary cortisol levels decreasing in both groups (p = 0.02). 2. Pain scores for both groups (n = 38) indicted mild to moderate pain during suctioning, with no significant difference in pain scores between groups.
conclusion1. KC did not affect salivary cortisol levels in preterm neonates, but levels in both the KC and SC groups decreased over time from DOL five to ten. Salivary cortisol may vary with age of infant. 2. Infants experience pain during routine suctioning and may require pain management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.